Evaluation of varicella-zoster antiviral drugs by a nucleic acid hybridization assay

A simple nucleic acid hybridization assay was developed for the evaluation of antiviral compounds with activity against varicella-zoster virus. Antiviral-induced reduction in varicella-zoster virus DNA, as measured by hybridization with 32P-labeled probes, correlated with drug-induced inhibition of...

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Veröffentlicht in:	Antiviral research 1988-09, Vol.9 (6), p.367-377
Hauptverfasser:	Stanberry, Lawrence R., Myers, Martin G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents Acyclovir - pharmacology Animals Antiviral Agents - pharmacology Biological and medical sciences Cell Line Cytopathogenic Effect, Viral - drug effects DNA hybridization DNA Probes DNA, Viral - biosynthesis Drug Evaluation, Preclinical Fundamental and applied biological sciences. Psychology Herpesvirus 3, Human - drug effects Herpesvirus 3, Human - metabolism Humans Microbiology Nucleic Acid Hybridization Varicella-zoster virus Virology
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Zusammenfassung:	A simple nucleic acid hybridization assay was developed for the evaluation of antiviral compounds with activity against varicella-zoster virus. Antiviral-induced reduction in varicella-zoster virus DNA, as measured by hybridization with 32P-labeled probes, correlated with drug-induced inhibition of viral cytopathic effect in cell culture. Three compounds were shown to be more potent than acyclovir at inhibiting varicella-zoster virus in vitro.
ISSN:	0166-3542 1872-9096
DOI:	10.1016/0166-3542(88)90038-1