Cognitive and emotional deficits in early stages of HIV infection: An event-related potentials study
1. 1. In order to inventory different Event-Related Potentials (ERP) modifications in HIV-infection the authors have evaluated 23 HIV-positive subjects and 12 HIV-negative subjects. ERP were recorded during an auditory oddball task. 2. 2. Electrophysiological results showed that the latency of the N...
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Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1996-11, Vol.20 (8), p.1303-1314 |
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Sprache: | eng |
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1. In order to inventory different Event-Related Potentials (ERP) modifications in HIV-infection the authors have evaluated 23 HIV-positive subjects and 12 HIV-negative subjects. ERP were recorded during an auditory oddball task.
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2. Electrophysiological results showed that the latency of the N100 component of the ERP was significantly increased in HIV-positive subjects compared to the HIV-negative subjects. The latency of the N200 component of the ERP showed a similar tendency which just failed to reach significance when considering HIV-positive subjects vs HIV negative subjects. This result was in agreement with the literature which reported increased latencies in HIV infection.
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3. Considering all subjects the authors have observed a correlation between the amplitude of the P300 and the emotional deficit. This correlation was stronger in subjects who presented an emotional deficit and was independent of any other psychopathological symptom.
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4. The use of ERP appeared to be a sensitive technique to detect subclinical manifestations in HIV asymptomatic subjects and therefore would help to identify subjects at higher risk for developing cognitive impairments. |
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ISSN: | 0278-5846 1878-4216 |
DOI: | 10.1016/S0278-5846(96)00127-3 |