Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol

A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effe...

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Veröffentlicht in:	Comptes rendus des seances de la Societe de biologie et de ses filiales 1988, Vol.182 (3), p.308-315
Hauptverfasser:	Mounié, J, Goudonnet, H, Serrar, M, Escousse, A, Truchot, R C
Format:	Artikel
Sprache:	fre
Schlagworte:	Animals Cholesterol, Dietary - administration & dosage Cytochrome P-450 Enzyme System - metabolism Hyperthyroidism - metabolism Male Microsomes, Liver - enzymology Microsomes, Liver - metabolism Phenobarbital - pharmacology Rats Rats, Inbred Strains Triiodothyronine - pharmacology Xenobiotics - metabolism
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