Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol

Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol

A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effe...

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Veröffentlicht in:Comptes rendus des seances de la Societe de biologie et de ses filiales 1988, Vol.182 (3), p.308-315
Hauptverfasser: Mounié, J, Goudonnet, H, Serrar, M, Escousse, A, Truchot, R C
Format: Artikel
Sprache:fre
Schlagworte:
Animals
Cholesterol, Dietary - administration & dosage
Cytochrome P-450 Enzyme System - metabolism
Hyperthyroidism - metabolism
Male
Microsomes, Liver - enzymology
Microsomes, Liver - metabolism
Phenobarbital - pharmacology
Rats
Rats, Inbred Strains
Triiodothyronine - pharmacology
Xenobiotics - metabolism
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Zusammenfassung:A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effects of phenobarbital but did not oppose its decreasing effect on maximal fluorescence of ANS and PNA introduced into the microsome suspensions.
ISSN:0037-9026