Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol
A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effe...
Gespeichert in:
| Veröffentlicht in: | Comptes rendus des seances de la Societe de biologie et de ses filiales 1988, Vol.182 (3), p.308-315 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | fre |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 3 |
| container_start_page | 308 |
| container_title | Comptes rendus des seances de la Societe de biologie et de ses filiales |
| container_volume | 182 |
| creator | Mounié, J Goudonnet, H Serrar, M Escousse, A Truchot, R C |
| description | A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effects of phenobarbital but did not oppose its decreasing effect on maximal fluorescence of ANS and PNA introduced into the microsome suspensions. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_78672942</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78672942</sourcerecordid><originalsourceid>FETCH-LOGICAL-p538-46e9764d54515b0f98c79f5bd267072a9302655ee45219c41abce9d2a31530453</originalsourceid><addsrcrecordid>eNo1UMtqwzAQ9KElDWk-oaBTe4lBlizbOpaQPsDQS-5GlldEIEuuJEPdv-mfVmnS08LOY2fnJltjTOucY1LdZdsQdI8xLgqOMVtlK8LrivBmnf0clAIZA3IK0R3b0ac8eq3d4PI2j6fFO6stIGdRPAEC-72MEJCHMDmbPA0g5fwfNkIUvTM6jGevL7Cu1y5qGZC-iL2ISKgIPi2kBxHgHxl00voFhXmazHKWy5MzEBLXmfvsVgkTYHudm-z4cjju3_L24_V9_9zmE6NNXlaQXioHVrKC9VjxRtZcsX4gVY1rIjhNRTAGUDJScFkWopfAByJowSguGd1kjxfbybvPOd3uRh0kGCMsuDl0dVPVhJckER-uxLkfYegmr8cUvrtWSn8BgEJz0g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78672942</pqid></control><display><type>article</type><title>Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Gallica Periodicals</source><creator>Mounié, J ; Goudonnet, H ; Serrar, M ; Escousse, A ; Truchot, R C</creator><creatorcontrib>Mounié, J ; Goudonnet, H ; Serrar, M ; Escousse, A ; Truchot, R C</creatorcontrib><description>A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effects of phenobarbital but did not oppose its decreasing effect on maximal fluorescence of ANS and PNA introduced into the microsome suspensions.</description><identifier>ISSN: 0037-9026</identifier><identifier>PMID: 2976298</identifier><language>fre</language><publisher>France</publisher><subject>Animals ; Cholesterol, Dietary - administration & dosage ; Cytochrome P-450 Enzyme System - metabolism ; Hyperthyroidism - metabolism ; Male ; Microsomes, Liver - enzymology ; Microsomes, Liver - metabolism ; Phenobarbital - pharmacology ; Rats ; Rats, Inbred Strains ; Triiodothyronine - pharmacology ; Xenobiotics - metabolism</subject><ispartof>Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Vol.182 (3), p.308-315</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2976298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mounié, J</creatorcontrib><creatorcontrib>Goudonnet, H</creatorcontrib><creatorcontrib>Serrar, M</creatorcontrib><creatorcontrib>Escousse, A</creatorcontrib><creatorcontrib>Truchot, R C</creatorcontrib><title>Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol</title><title>Comptes rendus des seances de la Societe de biologie et de ses filiales</title><addtitle>C R Seances Soc Biol Fil</addtitle><description>A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effects of phenobarbital but did not oppose its decreasing effect on maximal fluorescence of ANS and PNA introduced into the microsome suspensions.</description><subject>Animals</subject><subject>Cholesterol, Dietary - administration & dosage</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Hyperthyroidism - metabolism</subject><subject>Male</subject><subject>Microsomes, Liver - enzymology</subject><subject>Microsomes, Liver - metabolism</subject><subject>Phenobarbital - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Triiodothyronine - pharmacology</subject><subject>Xenobiotics - metabolism</subject><issn>0037-9026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UMtqwzAQ9KElDWk-oaBTe4lBlizbOpaQPsDQS-5GlldEIEuuJEPdv-mfVmnS08LOY2fnJltjTOucY1LdZdsQdI8xLgqOMVtlK8LrivBmnf0clAIZA3IK0R3b0ac8eq3d4PI2j6fFO6stIGdRPAEC-72MEJCHMDmbPA0g5fwfNkIUvTM6jGevL7Cu1y5qGZC-iL2ISKgIPi2kBxHgHxl00voFhXmazHKWy5MzEBLXmfvsVgkTYHudm-z4cjju3_L24_V9_9zmE6NNXlaQXioHVrKC9VjxRtZcsX4gVY1rIjhNRTAGUDJScFkWopfAByJowSguGd1kjxfbybvPOd3uRh0kGCMsuDl0dVPVhJckER-uxLkfYegmr8cUvrtWSn8BgEJz0g</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Mounié, J</creator><creator>Goudonnet, H</creator><creator>Serrar, M</creator><creator>Escousse, A</creator><creator>Truchot, R C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol</title><author>Mounié, J ; Goudonnet, H ; Serrar, M ; Escousse, A ; Truchot, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p538-46e9764d54515b0f98c79f5bd267072a9302655ee45219c41abce9d2a31530453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Cholesterol, Dietary - administration & dosage</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Hyperthyroidism - metabolism</topic><topic>Male</topic><topic>Microsomes, Liver - enzymology</topic><topic>Microsomes, Liver - metabolism</topic><topic>Phenobarbital - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Triiodothyronine - pharmacology</topic><topic>Xenobiotics - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Mounié, J</creatorcontrib><creatorcontrib>Goudonnet, H</creatorcontrib><creatorcontrib>Serrar, M</creatorcontrib><creatorcontrib>Escousse, A</creatorcontrib><creatorcontrib>Truchot, R C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Comptes rendus des seances de la Societe de biologie et de ses filiales</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mounié, J</au><au>Goudonnet, H</au><au>Serrar, M</au><au>Escousse, A</au><au>Truchot, R C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol</atitle><jtitle>Comptes rendus des seances de la Societe de biologie et de ses filiales</jtitle><addtitle>C R Seances Soc Biol Fil</addtitle><date>1988</date><risdate>1988</risdate><volume>182</volume><issue>3</issue><spage>308</spage><epage>315</epage><pages>308-315</pages><issn>0037-9026</issn><abstract>A cholesterol rich diet fed to rats was found to increase the cytochrome P 450 content in hepatic microsomes. Furthermore, the variations of the same parameters promoted by 3,5,3'-triiodo-L-thyronine were strongly reduced in cholesterol supplemented rats. Cholesterol prevented the inducing effects of phenobarbital but did not oppose its decreasing effect on maximal fluorescence of ANS and PNA introduced into the microsome suspensions.</abstract><cop>France</cop><pmid>2976298</pmid><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9026 |
| ispartof | Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Vol.182 (3), p.308-315 |
| issn | 0037-9026 |
| language | fre |
| recordid | cdi_proquest_miscellaneous_78672942 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Gallica Periodicals |
| subjects | Animals Cholesterol, Dietary - administration & dosage Cytochrome P-450 Enzyme System - metabolism Hyperthyroidism - metabolism Male Microsomes, Liver - enzymology Microsomes, Liver - metabolism Phenobarbital - pharmacology Rats Rats, Inbred Strains Triiodothyronine - pharmacology Xenobiotics - metabolism |
| title | Effects of 3,5,3'-triiodo-L-thyronine on the enzymes responsible for the metabolism of xenobiotics in the rat after increase in the dietary supply of cholesterol |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T01%3A00%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%203,5,3'-triiodo-L-thyronine%20on%20the%20enzymes%20responsible%20for%20the%20metabolism%20of%20xenobiotics%20in%20the%20rat%20after%20increase%20in%20the%20dietary%20supply%20of%20cholesterol&rft.jtitle=Comptes%20rendus%20des%20seances%20de%20la%20Societe%20de%20biologie%20et%20de%20ses%20filiales&rft.au=Mouni%C3%A9,%20J&rft.date=1988&rft.volume=182&rft.issue=3&rft.spage=308&rft.epage=315&rft.pages=308-315&rft.issn=0037-9026&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E78672942%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78672942&rft_id=info:pmid/2976298&rfr_iscdi=true |