Extent of colocalization of serotonin and GABA in neurons of the ventral medulla oblongata in rat

The colocalization of serotonin (5-hydroxytryptamine; 5-HT) and γ-aminobutyric acid (GABA) in the ventral aspect of the rat medulla oblongata was studied using antibodies directed against 5-HT and GABA. Although 5-HT- and GABA-immunoreactive cell bodies were observed over the entire rostral-caudal e...

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Veröffentlicht in:	Brain research 1988-09, Vol.461 (1), p.169-174
Hauptverfasser:	Millhorn, David E., Ho¨kfelt, Tomas, Seroogy, Kim, Verhofstad, A.A.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptamine Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Coexistence Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - analysis Immunohistochemistry Male Medulla Oblongata - anatomy & histology Medulla Oblongata - cytology Neurons - cytology Neurotransmitter Nucleus raphe magnus Rat Rats Serotonin - analysis Vertebrates: nervous system and sense organs
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Zusammenfassung:	The colocalization of serotonin (5-hydroxytryptamine; 5-HT) and γ-aminobutyric acid (GABA) in the ventral aspect of the rat medulla oblongata was studied using antibodies directed against 5-HT and GABA. Although 5-HT- and GABA-immunoreactive cell bodies were observed over the entire rostral-caudal extent of the ventral medulla, the colocalization of these two classical neurotransmitters in single cells was, for the most part, limited to a region that corresponds anatomically to nucleus raphe magnus/nucleus paragigantocellularis. Schematic drawings showing the distribution of 5-HT/GABA cell bodies in the ventral medulla are provided.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(88)90736-6