Suppression of HBsAg Production in PLC/PRF/5 Human Hepatoma Cell Line by Interferons

Recombinant human interferon alpha 2a as well as natural human interferons α and β significantly suppressed the production of hepatitis B surface antigen by PLC/PRF/5 cells (which have been established from a human primary hepatocellular carcinoma and proven to carry the hepatitis B virus DNA) and i...

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Veröffentlicht in:	MICROBIOLOGY and IMMUNOLOGY 1988, Vol.32(11), pp.1119-1126
Hauptverfasser:	Yamashita, Yumi, Koike, Kaori, Takaoki, Muneo, Matsuda, Shinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - biosynthesis Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Carcinoma, Hepatocellular - immunology Carcinoma, Hepatocellular - microbiology Carcinoma, Hepatocellular - therapy Cell Division - drug effects Fundamental and applied biological sciences. Psychology Fundamental immunology Genes, Viral - drug effects Hepatitis B Surface Antigens - analysis Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - genetics Humans Immunobiology Immunotherapy Interferon alpha-2 Interferon Type I - pharmacology Interferon-alpha - pharmacology Kinetics Liver Neoplasms - immunology Liver Neoplasms - microbiology Liver Neoplasms - therapy Miscellaneous Recombinant Proteins Regulatory factors and their cellular receptors Tumor Cells, Cultured - immunology Tumor Cells, Cultured - microbiology
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Beschreibung
Zusammenfassung:	Recombinant human interferon alpha 2a as well as natural human interferons α and β significantly suppressed the production of hepatitis B surface antigen by PLC/PRF/5 cells (which have been established from a human primary hepatocellular carcinoma and proven to carry the hepatitis B virus DNA) and inhibited proliferation of these cells in vitro. However, the production of α-fetoprotein by PLC/PRF/5 cells was less significantly affected by any of the interferons. These results suggest that these interferons not only suppress cellular proliferation but also selectively inhibit the action of the HBV gene which is persistently present in these cells.
ISSN:	0385-5600 1348-0421
DOI:	10.1111/j.1348-0421.1988.tb01476.x