The sodium pump becomes a family

The sodium pump becomes a family

The sodium pump, long recognized as central to the maintenance of Na + and K + ionic gradients, has gained a new personality, or we should say, set of personalities. Its catalytic subunit (α) and probably also its glycoprotein subunit (β) are encoded by several genes that are differentially expresse...

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Veröffentlicht in:Trends in Neurosciences 1988-07, Vol.11 (7), p.325-328
1. Verfasser: Fambrough, Douglas M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Humans
Protein Conformation
Sodium-Potassium-Exchanging ATPase - analysis
Sodium-Potassium-Exchanging ATPase - metabolism
Sodium-Potassium-Exchanging ATPase - physiology
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Zusammenfassung:The sodium pump, long recognized as central to the maintenance of Na + and K + ionic gradients, has gained a new personality, or we should say, set of personalities. Its catalytic subunit (α) and probably also its glycoprotein subunit (β) are encoded by several genes that are differentially expressed in different cell types. Of what physiological or regulatory relevance is this variety? The answers probably lie at many different levels of biological complexity.
ISSN:0166-2236
1878-108X
DOI:10.1016/0166-2236(88)90096-3