Reduced negative surface charge on arterial endothelium of diabetic rats

Reduced negative surface charge on arterial endothelium of diabetic rats

Cationized ferritin binding was used to measure negative surface charge on endothelium of large arteries in streptozotocin-induced diabetic rats and normal control rats. The negative charge was significantly lower in the diabetic animals (p less than 0.01). This change, possibly related to glycosyla...

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Veröffentlicht in:Diabetologia 1988-08, Vol.31 (8), p.618-620
Hauptverfasser: RAZ, I, HAVIVI, Y, YAROM, R
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Arteries - metabolism
Biological and medical sciences
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Endothelium, Vascular - metabolism
Endothelium, Vascular - ultrastructure
Ferritins - metabolism
Male
Medical sciences
Microscopy, Electron
Rats
Rats, Inbred Strains
Reference Values
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Zusammenfassung:Cationized ferritin binding was used to measure negative surface charge on endothelium of large arteries in streptozotocin-induced diabetic rats and normal control rats. The negative charge was significantly lower in the diabetic animals (p less than 0.01). This change, possibly related to glycosylation, may lead to altered vascular permeability and may be of importance in the vascular pathology of diabetes.
ISSN:0012-186X
1432-0428
DOI:10.1007/BF00264770