Evidence that type A CCK receptors facilitate dopamine efflux in rat brain

Evidence that type A CCK receptors facilitate dopamine efflux in rat brain

The authors have used a novel and highly selective Type A CCK receptor antagonist to demonstrate that these binding sites mediate an important and selective interaction between CCK and mesolimbic DA terminals in the nucleus accumbens.

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Veröffentlicht in:European journal of pharmacology 1988-08, Vol.152 (3), p.371-372
Hauptverfasser: Vickroy, Thomas W., Bianchi, Bruce R., Kerwin, James F., Kopecka, Hana, Nadzan, Alex M.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Cell receptors
Cell structures and functions
Cholecystokinin - pharmacology
Dopamine - metabolism
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Male
Molecular and cellular biology
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Rats
Rats, Inbred Strains
Receptors, Cholecystokinin - metabolism
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Beschreibung
Zusammenfassung:The authors have used a novel and highly selective Type A CCK receptor antagonist to demonstrate that these binding sites mediate an important and selective interaction between CCK and mesolimbic DA terminals in the nucleus accumbens.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(88)90735-2