Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats

From a human fetal-brain cDNA library we isolated two novel genes encoding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of chicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel-like, type 2), conta...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1996-12, Vol.38 (3), p.273-276
Hauptverfasser:	Watanabe, Takeshi K., Katagiri, Toyomasa, Suzuki, Mikio, Shimizu, Fumio, Fujiwara, Tsutomu, Kanemoto, Naohide, Nakamura, Yusuke, Hirai, Yoshikatsu, Maekawa, Hiroumi, Takahashi, Ei-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Animals Base Sequence Biological and medical sciences Brain - embryology Brain - metabolism Chickens - genetics Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 12 - genetics Cloning, Molecular DNA, Complementary - genetics Epidermal Growth Factor - chemistry Fetal Proteins - genetics Fetus - metabolism Fundamental and applied biological sciences. Psychology Genes. Genome Humans In Situ Hybridization, Fluorescence Kidney - embryology Kidney - metabolism Molecular and cellular biology Molecular genetics Molecular Sequence Data Nerve Tissue Proteins - genetics Open Reading Frames Sequence Homology, Amino Acid
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Zusammenfassung:	From a human fetal-brain cDNA library we isolated two novel genes encoding peptides containing six EGF-like repeats. Both showed significant homologies with nel, a gene strongly expressed in neural tissues of chicken. The cDNAs, designated NELL1 (nel-like, type 1) and NELL2 (nel-like, type 2), contained open reading frames encoding 810 and 816 amino acids, respectively. NELL2 is strongly expressed in brain of adult and fetus but only weakly in fetal kidney. NELL1 and NELL2 were mapped by FISH to chromosomal bands 11p15.1–p15.2 and 12q13.11–q13.12, respectively.
ISSN:	0888-7543 1089-8646
DOI:	10.1006/geno.1996.0628