The influence of atenolol and prazosin on serum lipids and atherosclerosis in minipigs fed a hyperlipidemic diet

1. 1. The effect of the adrenergic blockers prazosin and atenolol were tested in hypercholesterolemic Göttingen minipigs. 2. 2. After 1 yr there was a significant reduction of plasma triglycerides and total cholesterol in the medicated animals as compared to untreated ones. 3. 3. No significant diff...

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Veröffentlicht in:	General pharmacology 1988, Vol.19 (5), p.719-724
Hauptverfasser:	Nafstad, Inger, Tollersrud, Sverre, Eriksen, Karin, Helgeland, Anders, Solberg, Lars Åge, Bredesen, Jan, Dale, Ola
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - blood Arteriosclerosis - pathology Atenolol - pharmacology Body Weight - drug effects Cholesterol, Dietary - administration & dosage Diet Female gamma-Glutamyltransferase - blood Glutathione - blood Hyperlipidemias - blood Lipids - blood Liver - pathology Male Prazosin - pharmacology Swine Swine, Miniature Vitamin E - blood
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Zusammenfassung:	1. 1. The effect of the adrenergic blockers prazosin and atenolol were tested in hypercholesterolemic Göttingen minipigs. 2. 2. After 1 yr there was a significant reduction of plasma triglycerides and total cholesterol in the medicated animals as compared to untreated ones. 3. 3. No significant difference in atherosclerotic lesions was observed.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(88)90135-8