Gamma-interferon activation of macrophages for killing of Paracoccidioides brasiliensis and evidence for nonoxidative mechanisms

Gamma-interferon activation of macrophages for killing of Paracoccidioides brasiliensis and evidence for nonoxidative mechanisms

Fungicidal activity of murine peritoneal macrophages for the yeast form of the dimorphic fungal pathogen P. brasiliensis was studied. Killing was assessed by reduction of colony forming units (CFU) using a new medium which has a good plating efficiency. Resident peritoneal macrophages phagocytosed b...

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Veröffentlicht in:International journal of immunopharmacology 1988, Vol.10 (8), p.945-952
Hauptverfasser: Brummer, Elmer, Hanson, Linda H., Stevens, David A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Concanavalin A - pharmacology
Cytotoxicity, Immunologic
Dose-Response Relationship, Immunologic
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Interferon-gamma - administration & dosage
Interferon-gamma - pharmacology
Macrophage Activation
Macrophages - immunology
Macrophages - metabolism
Male
Mice
Mice, Inbred BALB C
Microbiology
Mitosporic Fungi - immunology
Mycology
Oxygen - metabolism
Paracoccidioides - immunology
Paracoccidioides brasiliensis
Pathogenicity, host-agent relations, miscellaneous strains, epidemiology
Phagocytosis
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Zusammenfassung:Fungicidal activity of murine peritoneal macrophages for the yeast form of the dimorphic fungal pathogen P. brasiliensis was studied. Killing was assessed by reduction of colony forming units (CFU) using a new medium which has a good plating efficiency. Resident peritoneal macrophages phagocytosed but did not kill P. brasiliensis. Macrophages treated overnight with recombinant γ-interferon (IFN), lymph node cells plus concanavalin A (Con A) or Con A-stimulated spleen cell culture supernatants (Con A Sup) reproducibly killed three different isolates of P. brasiliensis (35 − 55%, P
ISSN:0192-0561
1879-3495
DOI:10.1016/0192-0561(88)90041-0