Anaesthesia and angiotensin-converting enzyme inhibitors. The effect of enalapril on peri-operative cardiovascular stability

The effect of enalapril pretreatment on the haemodynamic response to tracheal intubation and surgical stimulation has been studied in 22 patients. Enalapril 5 mg given 4 hours before operation was associated with a significant reduction in the pressor response associated with intubation (p less than...

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Veröffentlicht in:	Anaesthesia 1988-11, Vol.43 (11), p.935-938
Hauptverfasser:	Yates, A P, Hunter, D N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia, General Enalapril - therapeutic use Female Hemodynamics - drug effects Humans Hypertension - prevention & control Intubation, Intratracheal Premedication Renin-Angiotensin System - drug effects Surgical Procedures, Operative Time Factors
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Zusammenfassung:	The effect of enalapril pretreatment on the haemodynamic response to tracheal intubation and surgical stimulation has been studied in 22 patients. Enalapril 5 mg given 4 hours before operation was associated with a significant reduction in the pressor response associated with intubation (p less than 0.05) and surgical stimulation (p less than 0.005) compared with control. Heart rate changes were similar in the two groups. The role of the renin-angiotensin system in relation to the pressor response to sympathetic stimulation is discussed and it is concluded that angiotensin-converting enzyme inhibitors may help improve peri-operative cardiovascular stability.
ISSN:	0003-2409 1365-2044
DOI:	10.1111/j.1365-2044.1988.tb05655.x