192Ir endovascular brachytherapy for avoidance of intimal hyperplasia after percutaneous transluminal angioplasty and stent implantation in peripheral vessels: 6 years of experience

Purpose : Percutaneous transluminal angioplasty (PTA) with or without stentimplantation is the accepted stadard in the therapy of occlusive arterial disease. Despite improvements in the technique and medical equipment, there is still a restenosis rate of up to 40%. A high-dose-rate afterloading tech...

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Veröffentlicht in:International journal of radiation oncology, biology, physics biology, physics, 1996-11, Vol.36 (4), p.835-840
Hauptverfasser: Schopohl, Bernhard, Liermann, Dieter, Pohlit, Lotte Jülling, Heyd, Reinhard, Strassmann, Gerd, Bauersachs, Rupert, Schulte-Huermann, Detlef, Rahl, Claus Guido, Manegold, Karl-Heinz, Kollath, Jürgen, Böttcher, Heinz D.
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Sprache:eng
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Zusammenfassung:Purpose : Percutaneous transluminal angioplasty (PTA) with or without stentimplantation is the accepted stadard in the therapy of occlusive arterial disease. Despite improvements in the technique and medical equipment, there is still a restenosis rate of up to 40%. A high-dose-rate afterloading technique to avoid vascular stenosis or occlusion after PTA and subsequent stent implantation caused by initmal hyperplasia is presented with longterm results. Methods and Materials : Intravascular brachytherapy with a 10-Ci 192Ir source was performed in cases of recurrent vascular occlusion or stenosis which appeared within 6 months after a previous PTA. After recanalization by PTA and stentimplantaion, a 9-Fr ReKa catheter was positioned within the stent to center the applicator with its tip 2 cm below the stent. This catheter served as a guide for a 5-Fr flexible applicator. After this procedure the isodose was calculated and a 12-gy to 3-mm source distance was applied. The procedure was followed by 72 h of heparinization. Results : From May 1990 to June 1996, 28 patients (21 male and seven female) wre treated with endovascular brachytherapy. All patients had a clincally relevant restenosis or reocclusion of the arteria femoralis. Follow-up time ranged from 1 to 71 months. Twenty-eight patients had a sufficient follow-up time; 25 of these patients were examined. Twenty-one patients had treated vessel segments; four patients had no flow in the treated area. Two patients moved away with unknown addresses, and one patient died without any follow-up examination. Radiation-associated side effects were not notable. Conclusion : Intraluminal brachytherapy with 192Ir is a safe and useful procedure to avoid endovascular hyperplasia after transluminal percutaneous angioplasty.
ISSN:0360-3016
1879-355X
DOI:10.1016/S0360-3016(96)00435-X