Serotonin and autism: Biochemical and molecular biology features
Whole blood and urinary levels of serotonin (5-hydroxytryptamine; 5-HT) and the derivative urinary 5-hydroxyindoleacetic acid (5-HIAA) were measured in normal and autistic subjects. An association was tested between autism and a marker coding for the 5-HT 2A serotonergic receptor gene. Significant g...
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| Veröffentlicht in: | Psychiatry research 1996-11, Vol.65 (1), p.33-43 |
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| container_title | Psychiatry research |
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| creator | Hérault, Josiane Petit, Elisabeth Martineau, Joëlle Cherpi, Catherine Perrot, Anne Barthélémy, Catherine Lelord, Gilbert Müh, Jean Pierre |
| description | Whole blood and urinary levels of serotonin (5-hydroxytryptamine; 5-HT) and the derivative urinary 5-hydroxyindoleacetic acid (5-HIAA) were measured in normal and autistic subjects. An association was tested between autism and a marker coding for the 5-HT
2A serotonergic receptor gene. Significant group (high urinary 5-HT and low whole blood 5-HT in autism) and age effects (urinary 5-HT decrease with age) were found. Moreover, whole blood 5-HT levels were correlated with clinical state. No differences in allele and genotype frequencies for the 5-HT
2A receptor marker were found in this autistic population compared with age-matched healthy students. |
| doi_str_mv | 10.1016/0165-1781(96)02882-X |
| format | Article |
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2A receptor marker were found in this autistic population compared with age-matched healthy students.</description><subject>5-Hydroxyindoleacetic acid</subject><subject>5-Hydroxytryptamine 2A receptor</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Alleles</subject><subject>Autistic Disorder - blood</subject><subject>Autistic Disorder - genetics</subject><subject>Autistic Disorder - urine</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child psychiatry</subject><subject>Child, Preschool</subject><subject>Developmental disorders</subject><subject>Female</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Infantile autism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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2A serotonergic receptor gene. Significant group (high urinary 5-HT and low whole blood 5-HT in autism) and age effects (urinary 5-HT decrease with age) were found. Moreover, whole blood 5-HT levels were correlated with clinical state. No differences in allele and genotype frequencies for the 5-HT
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| ispartof | Psychiatry research, 1996-11, Vol.65 (1), p.33-43 |
| issn | 0165-1781 1872-7123 |
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| subjects | 5-Hydroxyindoleacetic acid 5-Hydroxytryptamine 2A receptor Adolescent Adult Alleles Autistic Disorder - blood Autistic Disorder - genetics Autistic Disorder - urine Biological and medical sciences Child Child clinical studies Child psychiatry Child, Preschool Developmental disorders Female Genetics Genotype Humans Infantile autism Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin - blood Serotonin - genetics Serotonin - urine |
| title | Serotonin and autism: Biochemical and molecular biology features |
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