Serotonin and autism: Biochemical and molecular biology features

Whole blood and urinary levels of serotonin (5-hydroxytryptamine; 5-HT) and the derivative urinary 5-hydroxyindoleacetic acid (5-HIAA) were measured in normal and autistic subjects. An association was tested between autism and a marker coding for the 5-HT 2A serotonergic receptor gene. Significant g...

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Veröffentlicht in:	Psychiatry research 1996-11, Vol.65 (1), p.33-43
Hauptverfasser:	Hérault, Josiane, Petit, Elisabeth, Martineau, Joëlle, Cherpi, Catherine, Perrot, Anne, Barthélémy, Catherine, Lelord, Gilbert, Müh, Jean Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxyindoleacetic acid 5-Hydroxytryptamine 2A receptor Adolescent Adult Alleles Autistic Disorder - blood Autistic Disorder - genetics Autistic Disorder - urine Biological and medical sciences Child Child clinical studies Child psychiatry Child, Preschool Developmental disorders Female Genetics Genotype Humans Infantile autism Male Medical sciences Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serotonin - blood Serotonin - genetics Serotonin - urine
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Beschreibung
Zusammenfassung:	Whole blood and urinary levels of serotonin (5-hydroxytryptamine; 5-HT) and the derivative urinary 5-hydroxyindoleacetic acid (5-HIAA) were measured in normal and autistic subjects. An association was tested between autism and a marker coding for the 5-HT 2A serotonergic receptor gene. Significant group (high urinary 5-HT and low whole blood 5-HT in autism) and age effects (urinary 5-HT decrease with age) were found. Moreover, whole blood 5-HT levels were correlated with clinical state. No differences in allele and genotype frequencies for the 5-HT 2A receptor marker were found in this autistic population compared with age-matched healthy students.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/0165-1781(96)02882-X