Pharmacokinetics of fluoride absorbed from dried seafoods by healthy adults
Dried seafoods are a rich source of fluoride (F). The systemic availability of F from seafoods was studied in 3 healthy adults. The plasma concentration and urinary excretion of F for 24 h following the ingestion of 3.87 +/- 0.32 mg F (mean +/- SD) in seafoods were compared with plasma and urine dat...
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Veröffentlicht in: | European journal of clinical pharmacology 1988-01, Vol.34 (5), p.489-493 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Dried seafoods are a rich source of fluoride (F). The systemic availability of F from seafoods was studied in 3 healthy adults. The plasma concentration and urinary excretion of F for 24 h following the ingestion of 3.87 +/- 0.32 mg F (mean +/- SD) in seafoods were compared with plasma and urine data following oral administration of 3 mg F in aqueous solution. There was a marked reduction and delay in the absorption of F from seafoods. The relative bioavailability of F from seafoods was 40.8 +/- 5.1%. These findings should be taken into consideration when determining the optimum level of daily F intake. |
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ISSN: | 0031-6970 1432-1041 |
DOI: | 10.1007/BF01046707 |