The Biosynthetic Origins of Rebeccamycin

Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. Evidence is presented that suggests that the alpha-amino group of neither tryptophan uni...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1988-09, Vol.51 (5), p.937-940
Hauptverfasser:	Pearce, Cedric J, Doyle, Terence W, Forenza, Salvatore, Lam, Kin S, Schroeder, Daniel R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides Anti-Bacterial Agents - biosynthesis Antibiotics, Antineoplastic - biosynthesis Antiviral drugs Biological and medical sciences Biotechnology Carbazoles Fundamental and applied biological sciences. Psychology General pharmacology Glucose - metabolism Health. Pharmaceutical industry Indoles Industrial applications and implications. Economical aspects Magnetic Resonance Spectroscopy Medical sciences Methionine - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Production of active biomolecules Tryptophan - metabolism
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Beschreibung
Zusammenfassung:	Experimental evidence is presented to demonstrate that the antitumor-antibiotic rebeccamycin is biosynthesized by Saccharothrix aerocolonigenes from one unit of glucose, one of methionine, and two of tryptophan. Evidence is presented that suggests that the alpha-amino group of neither tryptophan unit provides the nitrogen of the phthalimide system.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50059a020