Neuroprotective effect of 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride, a novel inducer of nerve growth factor

We have identified 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS70...

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Veröffentlicht in:	Life sciences (1973) 1996, Vol.59 (25), p.2139-2146
Hauptverfasser:	Yamamoto, Kyoko, Yoshikawa, Ryoko, Okuyama, Shigeru, Takahashi, Yuki, Karasawa, Yasuko, Hino, Noriko, Miyoshi, Toshio, Araki, Hiroaki, Hanabusa, Kenji, Shirai, Hirofusa, Tomisawa, Kazuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - analogs & derivatives 2,2'-Dipyridyl - pharmacology Animals Arterial Occlusive Diseases - pathology Astrocytes - drug effects Astrocytes - metabolism astroglial cells Cell Death Cells, Cultured cerebral ischemia Female Gerbillinae Meriones unguiculatus Mice Mice, Inbred ICR Mongolian gerbil nerve growth factor Nerve Growth Factors - biosynthesis neuronal degeneration Neurons - cytology Neurons - drug effects Neuroprotective Agents - pharmacology neurotrophic factor Pregnancy
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