Neuroprotective effect of 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride, a novel inducer of nerve growth factor

Neuroprotective effect of 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine trihydrochloride, a novel inducer of nerve growth factor

We have identified 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS70...

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Veröffentlicht in:Life sciences (1973) 1996, Vol.59 (25), p.2139-2146
Hauptverfasser: Yamamoto, Kyoko, Yoshikawa, Ryoko, Okuyama, Shigeru, Takahashi, Yuki, Karasawa, Yasuko, Hino, Noriko, Miyoshi, Toshio, Araki, Hiroaki, Hanabusa, Kenji, Shirai, Hirofusa, Tomisawa, Kazuyuki
Format: Artikel
Sprache:eng
Schlagworte:
2,2'-Dipyridyl - analogs & derivatives
2,2'-Dipyridyl - pharmacology
Animals
Arterial Occlusive Diseases - pathology
Astrocytes - drug effects
Astrocytes - metabolism
astroglial cells
Cell Death
Cells, Cultured
cerebral ischemia
Female
Gerbillinae
Meriones unguiculatus
Mice
Mice, Inbred ICR
Mongolian gerbil
nerve growth factor
Nerve Growth Factors - biosynthesis
neuronal degeneration
Neurons - cytology
Neurons - drug effects
Neuroprotective Agents - pharmacology
neurotrophic factor
Pregnancy
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Zusammenfassung:We have identified 4′-(4-methylphenyl)-2,2′:6′,2-terpyridine: trihydrochloride (SS701), which belongs to a family of a small unique neuroprotective agents. SS701 accelerated the production of nerve growth factor (NGF) in cultured astroglial cells, dose- and time-dependently. In in vivo studies, SS701, when administered 30 min after induced cerebral ischemia, neuroprotective effects on delayed neuronal death in Mongolian gerbils were evident. The neuroprotective effects of SS701 against ischemia-induced delayed neuronal death are attributed to stimulation of the production of NGF.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(96)00570-X