Cosolvent solubilization and formulation of an aqueous injection of ketoprofen

Ketoprofen (1) an analgesic, antipyretic and anti-inflammatory agent, is practically insoluble in water. An increase in the aqueous solubility of 1 was attempted by various cosolvents. The solubility increased up to 8556 times (maximum) in case of ethanol while it was 33 times (minimum) in case of g...

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Veröffentlicht in:	Pharmazie 1996-10, Vol.51 (10), p.737-740
Hauptverfasser:	SINGHAI, A. K, JAIN, S, JAIN, N. K
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Drug Compounding Freeze Drying General pharmacology Hydrogen-Ion Concentration Injections Ketoprofen - administration & dosage Ketoprofen - chemistry Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility Solvents
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Zusammenfassung:	Ketoprofen (1) an analgesic, antipyretic and anti-inflammatory agent, is practically insoluble in water. An increase in the aqueous solubility of 1 was attempted by various cosolvents. The solubility increased up to 8556 times (maximum) in case of ethanol while it was 33 times (minimum) in case of glycerol. Using selected cosolvents and hydrotropes, aqueous injections of 1 were formulated.
ISSN:	0031-7144