Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine...

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Veröffentlicht in:Nature (London) 1988-12, Vol.336 (6200), p.690-692
Hauptverfasser: Moreau, Jean-Francois, Donaldson, Debra D, Bennett, Frances, Witek-Giannotti, JoAnn, Clark, Steven C, Wong, Gordon G
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Sprache:eng
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Zusammenfassung:Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.
ISSN:0028-0836
1476-4687
DOI:10.1038/336690a0