Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis
Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The p...
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| Veröffentlicht in: | The Journal of infectious diseases 1996-12, Vol.174 (6), p.1345-1347 |
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| container_title | The Journal of infectious diseases |
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| creator | Campos, José Román, Federico Georgiou, Marios García, Concepción Gómez-Lus, Rafael Cantón, Rafael Escobar, Hector Baquero, Fernando |
| description | Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for ⩾ 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without β-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. infiuenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment. |
| doi_str_mv | 10.1093/infdis/174.6.1345 |
| format | Article |
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Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for ⩾ 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without β-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. infiuenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/174.6.1345</identifier><identifier>PMID: 8940231</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adult ; Ampicillin Resistance ; Anti-Infective Agents - therapeutic use ; Antibiotics ; beta-Lactamases - metabolism ; Chloramphenicol Resistance ; Ciprofloxacin - therapeutic use ; Concise Communication ; Cystic fibrosis ; Cystic Fibrosis - microbiology ; Drug Resistance, Microbial ; Electrophoresis, Gel, Pulsed-Field ; Female ; Fluoroquinolones ; Gels ; Haemophilus ; Haemophilus Infections - drug therapy ; Haemophilus influenzae ; Haemophilus influenzae - drug effects ; Haemophilus influenzae - growth & development ; Humans ; Infections ; Male ; Microbial Sensitivity Tests ; Microbiology ; Molecular Epidemiology ; Polymorphism, Restriction Fragment Length ; Quinolones ; Sputum</subject><ispartof>The Journal of infectious diseases, 1996-12, Vol.174 (6), p.1345-1347</ispartof><rights>Copyright 1996 The University of Chicago</rights><rights>Copyright University of Chicago, acting through its Press Dec 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-5f4db3ee85fc7ca4f29ee22ed57c8ab0bd3abe74b60d8339ed544d0f554d95fa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30129971$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30129971$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8940231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campos, José</creatorcontrib><creatorcontrib>Román, Federico</creatorcontrib><creatorcontrib>Georgiou, Marios</creatorcontrib><creatorcontrib>García, Concepción</creatorcontrib><creatorcontrib>Gómez-Lus, Rafael</creatorcontrib><creatorcontrib>Cantón, Rafael</creatorcontrib><creatorcontrib>Escobar, Hector</creatorcontrib><creatorcontrib>Baquero, Fernando</creatorcontrib><title>Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for ⩾ 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without β-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. infiuenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment.</description><subject>Adult</subject><subject>Ampicillin Resistance</subject><subject>Anti-Infective Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>beta-Lactamases - metabolism</subject><subject>Chloramphenicol Resistance</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Concise Communication</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - microbiology</subject><subject>Drug Resistance, Microbial</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Female</subject><subject>Fluoroquinolones</subject><subject>Gels</subject><subject>Haemophilus</subject><subject>Haemophilus Infections - drug therapy</subject><subject>Haemophilus influenzae</subject><subject>Haemophilus influenzae - drug effects</subject><subject>Haemophilus influenzae - growth & development</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Epidemiology</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Quinolones</subject><subject>Sputum</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2LEzEUhoMoa3f1B3ghBC-8m24-J8mlFHcrFFzLCuJNyMyc2NT5qMkM7vrrN0NLBW-8SuB535McHoTeULKkxPDr0PsmpGuqxLJcUi7kM7SgkquiLCl_jhaEMFZQbcxLdJnSnhAieKku0IU2gjBOF2i3GfofxT3EDt9BTCGN0NeAB49X4RAH3w4Prg59sYWZuX7EawfdcNiFdko4v99O0P9xkK_4zo0B-jHh32Hc4dVjGkONb0IVh9x9hV541yZ4fTqv0Nebj_erdbH5fPtp9WFT1EKqsZBeNBUH0NLXqnbCMwPAGDRS1dpVpGq4q0CJqiSN5txkIERDvJSiMdI7foXeH-fm3_-aII22C6mGtnU9DFOySkvFCGf_DVKpheJc5-C7f4L7YYp9XsIyxg0jquQ5RI-hOm-bInh7iKFz8dFSYmdX9ujKZle2tLOr3Hl7GjxVHTTnxknOX75P4xDPmBPKjFEzL458tvZw5i7-tKXiStr1t-_2y3arzfpWW8afAM9sq8c</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Campos, José</creator><creator>Román, Federico</creator><creator>Georgiou, Marios</creator><creator>García, Concepción</creator><creator>Gómez-Lus, Rafael</creator><creator>Cantón, Rafael</creator><creator>Escobar, Hector</creator><creator>Baquero, Fernando</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis</title><author>Campos, José ; Román, Federico ; Georgiou, Marios ; García, Concepción ; Gómez-Lus, Rafael ; Cantón, Rafael ; Escobar, Hector ; Baquero, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-5f4db3ee85fc7ca4f29ee22ed57c8ab0bd3abe74b60d8339ed544d0f554d95fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Ampicillin Resistance</topic><topic>Anti-Infective Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>beta-Lactamases - metabolism</topic><topic>Chloramphenicol Resistance</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Concise Communication</topic><topic>Cystic fibrosis</topic><topic>Cystic Fibrosis - microbiology</topic><topic>Drug Resistance, Microbial</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Female</topic><topic>Fluoroquinolones</topic><topic>Gels</topic><topic>Haemophilus</topic><topic>Haemophilus Infections - drug therapy</topic><topic>Haemophilus influenzae</topic><topic>Haemophilus influenzae - drug effects</topic><topic>Haemophilus influenzae - growth & development</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Molecular Epidemiology</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Quinolones</topic><topic>Sputum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campos, José</creatorcontrib><creatorcontrib>Román, Federico</creatorcontrib><creatorcontrib>Georgiou, Marios</creatorcontrib><creatorcontrib>García, Concepción</creatorcontrib><creatorcontrib>Gómez-Lus, Rafael</creatorcontrib><creatorcontrib>Cantón, Rafael</creatorcontrib><creatorcontrib>Escobar, Hector</creatorcontrib><creatorcontrib>Baquero, Fernando</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campos, José</au><au>Román, Federico</au><au>Georgiou, Marios</au><au>García, Concepción</au><au>Gómez-Lus, Rafael</au><au>Cantón, Rafael</au><au>Escobar, Hector</au><au>Baquero, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>174</volume><issue>6</issue><spage>1345</spage><epage>1347</epage><pages>1345-1347</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for ⩾ 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without β-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. infiuenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>8940231</pmid><doi>10.1093/infdis/174.6.1345</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of infectious diseases, 1996-12, Vol.174 (6), p.1345-1347 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78572032 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Ampicillin Resistance Anti-Infective Agents - therapeutic use Antibiotics beta-Lactamases - metabolism Chloramphenicol Resistance Ciprofloxacin - therapeutic use Concise Communication Cystic fibrosis Cystic Fibrosis - microbiology Drug Resistance, Microbial Electrophoresis, Gel, Pulsed-Field Female Fluoroquinolones Gels Haemophilus Haemophilus Infections - drug therapy Haemophilus influenzae Haemophilus influenzae - drug effects Haemophilus influenzae - growth & development Humans Infections Male Microbial Sensitivity Tests Microbiology Molecular Epidemiology Polymorphism, Restriction Fragment Length Quinolones Sputum |
| title | Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis |
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