Long-Term Persistence of Ciprofloxacin-Resistant Haemophilus influenzae in Patients with Cystic Fibrosis

Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The p...

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Veröffentlicht in:The Journal of infectious diseases 1996-12, Vol.174 (6), p.1345-1347
Hauptverfasser: Campos, José, Román, Federico, Georgiou, Marios, García, Concepción, Gómez-Lus, Rafael, Cantón, Rafael, Escobar, Hector, Baquero, Fernando
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Sprache:eng
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Zusammenfassung:Ciprofloxacin has been a major advance in the treatment of chronic respiratory infections. Three patients with cystic fibrosis and colonized by 5 nontypeable Haemophilus influenzae strains exhibiting low- (MIC, 2 µg/mL) and high-level ciprofloxacin resistance (MICs, 16-32 µg/mL) are described. The patients had received several courses of ciprofloxacin. These MICs represent a decrease in ciprofloxacin susceptibility of 200-3200 times. Molecular epidemiologic methods demonstrated that 2 patients were chronically colonized by their own ciprofloxacin-resistant strains for ⩾ 15-17 months. Three strains showed simultaneous resistance to ampicillin and chloramphenicol by enzyme inactivation, and 2 had ampicillin resistance without β-lactamase activity. These data suggest that the emergence and long-term persistence of ciprofloxacin-resistant H. infiuenzae in patients with cystic fibrosis can be a consequence of antibiotic treatment.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/174.6.1345