Localization of the gene for X-linked Alport's syndrome

Localization of the gene for X-linked Alport's syndrome

Localization of the gene for X-linked Alport's syndrome. X-chromo-somal DNA probes defining various polymorphic DNA markers were used to study genetic linkage in three families with Alport's syndrome. With the DXS17 marker, only a single cross-over was observed in 26 informative meioses, a...

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Veröffentlicht in:Kidney international 1988-10, Vol.34 (4), p.507-510
Hauptverfasser: Brunner, Han, Schröder, Cock, van Bennekom, Cor, Lambermon, Eric, Tuerlings, Joep, Menzel, Daria, Olbing, Hermann, Monnens, Leo, Wieringa, Berend, Ropers, Hans-Hilger
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
DNA Probes
Female
Genetic Linkage
Glomerulonephritis
Humans
Male
Medical sciences
Nephritis, Hereditary - genetics
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
X Chromosome
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Zusammenfassung:Localization of the gene for X-linked Alport's syndrome. X-chromo-somal DNA probes defining various polymorphic DNA markers were used to study genetic linkage in three families with Alport's syndrome. With the DXS17 marker, only a single cross-over was observed in 26 informative meioses, and evidence for linkage was also obtained with the DXS11 marker. These data localize the gene for the X-linked form of Alport's syndrome to the middle of the long arm of the X chromosome.
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1988.210