ERYTHROMYCIN A 11, 12-METHYLENE ACETAL

Erythromycin A 11, 12-methylene acetal (5) and the corresponding 9-methoxime, 9-dihydro, and 8-hydroxy derivatives have been prepared and their antibacterial activities compared with those of erythromycin A and its 11, 12-cyclic carbonate. The simple methylene acetal 5 showed excellent activity agai...

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Veröffentlicht in:	Journal of antibiotics 1988/11/25, Vol.41(11), pp.1644-1648
Hauptverfasser:	HUNT, ERIC, KNOWLES, DAVID J. C., SHILLINGFORD, CHRISTINE, ZOMAYA, ISKANDER I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Erythromycin - chemical synthesis Erythromycin - pharmacology Exact sciences and technology Microbial Sensitivity Tests Organic chemistry Preparations and properties
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Zusammenfassung:	Erythromycin A 11, 12-methylene acetal (5) and the corresponding 9-methoxime, 9-dihydro, and 8-hydroxy derivatives have been prepared and their antibacterial activities compared with those of erythromycin A and its 11, 12-cyclic carbonate. The simple methylene acetal 5 showed excellent activity against Gram-positive organisms in vitro.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.41.1644