EFFECTS OF CELERY EXTRACT AND 3-N-BUTYLPHTHALIDE ON LIPID LEVELS IN GENETICALLY HYPERCHOLESTEROLAEMIC (RICO) RATS
SUMMARY 1. Aqueous celery extract was administered intraperitoneally to genetically hypercholesterolaemic (RICO) and normochol‐esterolaemic (RAIF) rats via Alzet osmotic pumps over a 13 day period. 2. The serum cholesterol concentration of the celery extract‐treated RICO rats was found to be signifi...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1996-03, Vol.23 (3), p.214-217 |
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| container_title | Clinical and experimental pharmacology & physiology |
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| creator | Tsi, D. Tan, BKH |
| description | SUMMARY
1. Aqueous celery extract was administered intraperitoneally to genetically hypercholesterolaemic (RICO) and normochol‐esterolaemic (RAIF) rats via Alzet osmotic pumps over a 13 day period.
2. The serum cholesterol concentration of the celery extract‐treated RICO rats was found to be significantly lower (P |
| doi_str_mv | 10.1111/j.1440-1681.1996.tb02598.x |
| format | Article |
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1. Aqueous celery extract was administered intraperitoneally to genetically hypercholesterolaemic (RICO) and normochol‐esterolaemic (RAIF) rats via Alzet osmotic pumps over a 13 day period.
2. The serum cholesterol concentration of the celery extract‐treated RICO rats was found to be significantly lower (P<0.05) than the control rats. Aqueous celery extract was effective in preventing the rise of cholesterol level in the RICO rats. However, no such observation was seen in the RAIF rats. The serum triglyceride level was unchanged in both strains of rats.
3. When 3‐n‐butylphthalide (BuPh), a unique component in celery, was administered in the same manner to the RICO and RAIF rats, it did not produce significant changes in the serum and liver lipid profiles of these rats. The activities of hepatic 3‐hydroxy‐3‐methylglutaryl CoA reductase in both strains of rats were also not significantly different from their respective controls.
4. Together with our recently reported thin‐layer chroma‐tography findings that BuPh was not detected in the aqueous celery extract, this study suggests that the effect of celery extract on serum cholesterol levels in the RICO rats could be attributed to chemical constituents other than BuPh.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1996.tb02598.x</identifier><identifier>PMID: 8934610</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>3-n-butylphthalide ; Animals ; Benzofurans - pharmacology ; Benzofurans - therapeutic use ; celery ; cholesterol ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cholesterol, HDL - metabolism ; genetically hypercholesterolaemic (RICO) rat ; HMG-CoA reductase ; Hydroxymethylglutaryl CoA Reductases - metabolism ; Hypercholesterolemia - blood ; Hypercholesterolemia - genetics ; Hypercholesterolemia - physiopathology ; Lipoproteins - blood ; Liver - drug effects ; Liver - metabolism ; Plant Extracts - pharmacology ; Rats ; tri-glycerides ; Triglycerides - blood ; Triglycerides - metabolism ; Vegetables</subject><ispartof>Clinical and experimental pharmacology & physiology, 1996-03, Vol.23 (3), p.214-217</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4074-d79451be5b345e1f2231ac4311d2f5549b32f2caeca0d667cc9e81414e9c21dc3</citedby><cites>FETCH-LOGICAL-c4074-d79451be5b345e1f2231ac4311d2f5549b32f2caeca0d667cc9e81414e9c21dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1996.tb02598.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1996.tb02598.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8934610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsi, D.</creatorcontrib><creatorcontrib>Tan, BKH</creatorcontrib><title>EFFECTS OF CELERY EXTRACT AND 3-N-BUTYLPHTHALIDE ON LIPID LEVELS IN GENETICALLY HYPERCHOLESTEROLAEMIC (RICO) RATS</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. Aqueous celery extract was administered intraperitoneally to genetically hypercholesterolaemic (RICO) and normochol‐esterolaemic (RAIF) rats via Alzet osmotic pumps over a 13 day period.
2. The serum cholesterol concentration of the celery extract‐treated RICO rats was found to be significantly lower (P<0.05) than the control rats. Aqueous celery extract was effective in preventing the rise of cholesterol level in the RICO rats. However, no such observation was seen in the RAIF rats. The serum triglyceride level was unchanged in both strains of rats.
3. When 3‐n‐butylphthalide (BuPh), a unique component in celery, was administered in the same manner to the RICO and RAIF rats, it did not produce significant changes in the serum and liver lipid profiles of these rats. The activities of hepatic 3‐hydroxy‐3‐methylglutaryl CoA reductase in both strains of rats were also not significantly different from their respective controls.
4. Together with our recently reported thin‐layer chroma‐tography findings that BuPh was not detected in the aqueous celery extract, this study suggests that the effect of celery extract on serum cholesterol levels in the RICO rats could be attributed to chemical constituents other than BuPh.</description><subject>3-n-butylphthalide</subject><subject>Animals</subject><subject>Benzofurans - pharmacology</subject><subject>Benzofurans - therapeutic use</subject><subject>celery</subject><subject>cholesterol</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, HDL - metabolism</subject><subject>genetically hypercholesterolaemic (RICO) rat</subject><subject>HMG-CoA reductase</subject><subject>Hydroxymethylglutaryl CoA Reductases - metabolism</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - genetics</subject><subject>Hypercholesterolemia - physiopathology</subject><subject>Lipoproteins - blood</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>tri-glycerides</subject><subject>Triglycerides - blood</subject><subject>Triglycerides - metabolism</subject><subject>Vegetables</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1q20AUhYfQkjppHiEwdFHahdT51U8XBXU8tgRTSchKUq8GaTQCu3adSDZx3r4SNt73bu7inPtd-AD4hJGLh_m2djFjyMFegF0chp67rxHhYeAer8DkEr0DE0QRd3Dgow_gpu_XCCGOPHoNroOQMg-jCXiRs5kU5QJmMyikksUSyt9lEYkSRukUUid1fj6US5XHZRypZCphlkKV5MkUKvko1QImKZzLVJaJiJRawniZy0LEmZKLUhaZiuSvRMAvRSKyr7CIysVH8L6tNr29O-9b8DCTpYgdlc1HhmMY8pnT-CHjuLa8poxb3BJCcWUYxbghLecsrClpiamsqVDjeb4xoQ0ww8yGhuDG0Fvw-cR97nYvB9vv9XbVG7vZVH_t7tBrP-A8INwbit9PRdPt-r6zrX7uVtuqe9MY6dG3XutRqh6l6tG3PvvWx-H4_vzlUG9tczk9Cx7yH6f8dbWxb_9B1kLmBLMB4JwAq35vjxdA1f3Rnk99rp_S-QAJ8pQ_Brqg_wAoqJTg</recordid><startdate>199603</startdate><enddate>199603</enddate><creator>Tsi, D.</creator><creator>Tan, BKH</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199603</creationdate><title>EFFECTS OF CELERY EXTRACT AND 3-N-BUTYLPHTHALIDE ON LIPID LEVELS IN GENETICALLY HYPERCHOLESTEROLAEMIC (RICO) RATS</title><author>Tsi, D. ; Tan, BKH</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4074-d79451be5b345e1f2231ac4311d2f5549b32f2caeca0d667cc9e81414e9c21dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>3-n-butylphthalide</topic><topic>Animals</topic><topic>Benzofurans - pharmacology</topic><topic>Benzofurans - therapeutic use</topic><topic>celery</topic><topic>cholesterol</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, HDL - metabolism</topic><topic>genetically hypercholesterolaemic (RICO) rat</topic><topic>HMG-CoA reductase</topic><topic>Hydroxymethylglutaryl CoA Reductases - metabolism</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - genetics</topic><topic>Hypercholesterolemia - physiopathology</topic><topic>Lipoproteins - blood</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>tri-glycerides</topic><topic>Triglycerides - blood</topic><topic>Triglycerides - metabolism</topic><topic>Vegetables</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsi, D.</creatorcontrib><creatorcontrib>Tan, BKH</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsi, D.</au><au>Tan, BKH</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF CELERY EXTRACT AND 3-N-BUTYLPHTHALIDE ON LIPID LEVELS IN GENETICALLY HYPERCHOLESTEROLAEMIC (RICO) RATS</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1996-03</date><risdate>1996</risdate><volume>23</volume><issue>3</issue><spage>214</spage><epage>217</epage><pages>214-217</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. Aqueous celery extract was administered intraperitoneally to genetically hypercholesterolaemic (RICO) and normochol‐esterolaemic (RAIF) rats via Alzet osmotic pumps over a 13 day period.
2. The serum cholesterol concentration of the celery extract‐treated RICO rats was found to be significantly lower (P<0.05) than the control rats. Aqueous celery extract was effective in preventing the rise of cholesterol level in the RICO rats. However, no such observation was seen in the RAIF rats. The serum triglyceride level was unchanged in both strains of rats.
3. When 3‐n‐butylphthalide (BuPh), a unique component in celery, was administered in the same manner to the RICO and RAIF rats, it did not produce significant changes in the serum and liver lipid profiles of these rats. The activities of hepatic 3‐hydroxy‐3‐methylglutaryl CoA reductase in both strains of rats were also not significantly different from their respective controls.
4. Together with our recently reported thin‐layer chroma‐tography findings that BuPh was not detected in the aqueous celery extract, this study suggests that the effect of celery extract on serum cholesterol levels in the RICO rats could be attributed to chemical constituents other than BuPh.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>8934610</pmid><doi>10.1111/j.1440-1681.1996.tb02598.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Clinical and experimental pharmacology & physiology, 1996-03, Vol.23 (3), p.214-217 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | 3-n-butylphthalide Animals Benzofurans - pharmacology Benzofurans - therapeutic use celery cholesterol Cholesterol - blood Cholesterol, HDL - blood Cholesterol, HDL - metabolism genetically hypercholesterolaemic (RICO) rat HMG-CoA reductase Hydroxymethylglutaryl CoA Reductases - metabolism Hypercholesterolemia - blood Hypercholesterolemia - genetics Hypercholesterolemia - physiopathology Lipoproteins - blood Liver - drug effects Liver - metabolism Plant Extracts - pharmacology Rats tri-glycerides Triglycerides - blood Triglycerides - metabolism Vegetables |
| title | EFFECTS OF CELERY EXTRACT AND 3-N-BUTYLPHTHALIDE ON LIPID LEVELS IN GENETICALLY HYPERCHOLESTEROLAEMIC (RICO) RATS |
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