Semisynthetic Modification of Antibiotic Lincomycin

The present paper describes our results on the chemical modification of clindamycin. During our work a primary goal was to perform syntheses of the new antibiotic analogues which do not require temporary protection of the existing functions of the starting molecules. Nucleophilic substitution of the...

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Veröffentlicht in:	Journal of antibiotics 1996/09/25, Vol.49(9), pp.941-943
Hauptverfasser:	SZTARICSKAI, FERENC, DINYA, ZOLTÁN, PUSKÁS, MARIA M., BATTA, GYULA
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Azides - chemical synthesis Azides - chemistry Azides - pharmacology Biological and medical sciences Clindamycin - analogs & derivatives Clindamycin - chemistry Lincomycin - analogs & derivatives Lincomycin - chemical synthesis Lincomycin - chemistry Lincomycin - pharmacology Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The present paper describes our results on the chemical modification of clindamycin. During our work a primary goal was to perform syntheses of the new antibiotic analogues which do not require temporary protection of the existing functions of the starting molecules. Nucleophilic substitution of the 7(S)-chlorine atom of clindamycin offers the synthesis of novel antibiotic analogues modified at position C-7.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.49.941