Elevation of either axoplasmic norepinephrine or sodium level induced release of norepinephrine from cardiac sympathetic nerve terminals
Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under two different conditions: (1) local administration of a monoamine oxidase inhibitor (pargyline, 1, 10 mM), (2) local administration of a Na,K-ATPase inhibitor (ouabain, 10,...
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| Veröffentlicht in: | Brain research 1996-10, Vol.737 (1), p.343-346 |
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| container_end_page | 346 |
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| container_title | Brain research |
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| creator | Yamazaki, Toji Akiyama, Tsuyoshi Kitagawa, Hirotoshi Takauchi, Yuji Kawada, Toru |
| description | Using dialysis technique, prominent accumulation of norepinephrine (NE) in the myocardial interstitial space was observed under two different conditions: (1) local administration of a monoamine oxidase inhibitor (pargyline, 1, 10 mM), (2) local administration of a Na,K-ATPase inhibitor (ouabain, 10, 100 μM). Further, pretreatment with a vesicle uptake inhibitor (reserpine, 10 μM) augmented these responses. Either condition independently caused endogenous NE release and a brisk increase in dialysate NE levels might occur as a consequence of non-exocytotic release of NE. |
| doi_str_mv | 10.1016/0006-8993(96)00953-5 |
| format | Article |
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| ispartof | Brain research, 1996-10, Vol.737 (1), p.343-346 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antihypertensive Agents - pharmacology Axons - chemistry Axons - metabolism Cardiotonic Agents - pharmacology Cats Dialysis Exocytosis - physiology Female Ganglia, Sympathetic - drug effects Ganglia, Sympathetic - enzymology Heart - innervation Male Microdialysis Monoamine Oxidase Inhibitors - pharmacology Na,K-ATPase Non-exocytotic release Noradrenaline Norepinephrine - metabolism Ouabain Ouabain - pharmacology Pargyline Pargyline - pharmacology Reserpine - pharmacology Sodium - metabolism Sodium-Potassium-Exchanging ATPase - metabolism |
| title | Elevation of either axoplasmic norepinephrine or sodium level induced release of norepinephrine from cardiac sympathetic nerve terminals |
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