Pyrrolosporin A, a New Antitumor Antibiotic from Micromonospora sp. C39217-R109-7: II. Isolation, Physico-chemical Properties, Spectroscopic Study and X-ray Analysis

Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-a-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (CIS). The structure was determin...

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Veröffentlicht in:	Journal of antibiotics 1996/09/25, Vol.49(9), pp.865-872
Hauptverfasser:	SCHROEDER, DANIEL R., COLSON, KIMBERLY L., KLOHR, STEVE E., LEE, MIKE S., MATSON, JAMES A., BRINEN, LINDA S., CLARDY, JON
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - metabolism Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - metabolism Antineoplastic agents Biological and medical sciences Crystallography, X-Ray General aspects Macrolides Magnetic Resonance Spectroscopy Medical sciences Micromonospora Micromonospora - chemistry Micromonospora - metabolism Molecular Structure Pharmacology. Drug treatments Spectrometry, Mass, Fast Atom Bombardment
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Zusammenfassung:	Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-a-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (CIS). The structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.49.865