Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells
We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effe...
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| Veröffentlicht in: | Neuroreport 1996-09, Vol.7 (13), p.2167-2170 |
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| container_title | Neuroreport |
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| creator | Aarnisalo, Antti M Vainio, Petri J Männistö, Pekka T Vasar, Eero Tuominen, Raimo K |
| description | We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells. |
| doi_str_mv | 10.1097/00001756-199609020-00022 |
| format | Article |
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Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/00001756-199609020-00022</identifier><identifier>PMID: 8930982</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adrenal Medulla - metabolism ; Adrenals. Interrenals ; Adrenomedullary hormones. 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Psychology ; Hormone Antagonists - pharmacology ; Inositol Phosphates - metabolism ; Kinetics ; Phenylurea Compounds ; Receptor, Cholecystokinin A ; Receptors, Cholecystokinin - antagonists & inhibitors ; Receptors, Cholecystokinin - physiology ; Tetragastrin - pharmacology ; Vertebrates: endocrinology</subject><ispartof>Neuroreport, 1996-09, Vol.7 (13), p.2167-2170</ispartof><rights>Lippincott-Raven Publishers.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2312-6b454cc397093ad99561c8af1703466958c3c51cfccc214902c601399524cf73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2475583$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8930982$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aarnisalo, Antti M</creatorcontrib><creatorcontrib>Vainio, Petri J</creatorcontrib><creatorcontrib>Männistö, Pekka T</creatorcontrib><creatorcontrib>Vasar, Eero</creatorcontrib><creatorcontrib>Tuominen, Raimo K</creatorcontrib><title>Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells.</description><subject>Adrenal Medulla - metabolism</subject><subject>Adrenals. Interrenals</subject><subject>Adrenomedullary hormones. Regulation</subject><subject>Animals</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Cells, Cultured</subject><subject>Ceruletide - pharmacology</subject><subject>Chromaffin Cells - drug effects</subject><subject>Chromaffin Cells - metabolism</subject><subject>Devazepide</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone Antagonists - pharmacology</subject><subject>Inositol Phosphates - metabolism</subject><subject>Kinetics</subject><subject>Phenylurea Compounds</subject><subject>Receptor, Cholecystokinin A</subject><subject>Receptors, Cholecystokinin - antagonists & inhibitors</subject><subject>Receptors, Cholecystokinin - physiology</subject><subject>Tetragastrin - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOAjEUhhujQUQfwWQWxt1orzPTJSFeQ-KGhbumHNow0pliOwPh7S2C7OymSf_v9LTfQSgj-IFgWT7itEgpipxIWWCJKc7TCaVnaEh4yXIhqs9zNMRSyJzLQlyiqxi_EiIxqQZoUEmGZUWH6P1pUy9MCyazPmSw9M7ALnZ-Vbd1O86CAbPufIhZ3WZzv6lbk-lFMK12CQ6-0damBIxz8RpdWO2iuTnuIzR7fppNXvPpx8vbZDzNgTJC82LOBQdgssSS6YWUoiBQaUtKzHhRSFEBA0HAAgAlPP0NCkxY4igHW7IRuj9cuw7-uzexU00d9w_QrfF9VGUluKSEJLA6gBB8jMFYtQ51o8NOEaz2FtWfRXWyqH4tptLbY49-3pjFqfCoLeV3x1xH0M4G3UIdTxjlZRoASxg_YFvvOhPiyvVbE9TSaNct1X8zZD8taIii</recordid><startdate>19960902</startdate><enddate>19960902</enddate><creator>Aarnisalo, Antti M</creator><creator>Vainio, Petri J</creator><creator>Männistö, Pekka T</creator><creator>Vasar, Eero</creator><creator>Tuominen, Raimo K</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960902</creationdate><title>Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells</title><author>Aarnisalo, Antti M ; Vainio, Petri J ; Männistö, Pekka T ; Vasar, Eero ; Tuominen, Raimo K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2312-6b454cc397093ad99561c8af1703466958c3c51cfccc214902c601399524cf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenal Medulla - metabolism</topic><topic>Adrenals. Interrenals</topic><topic>Adrenomedullary hormones. Regulation</topic><topic>Animals</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Cells, Cultured</topic><topic>Ceruletide - pharmacology</topic><topic>Chromaffin Cells - drug effects</topic><topic>Chromaffin Cells - metabolism</topic><topic>Devazepide</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone Antagonists - pharmacology</topic><topic>Inositol Phosphates - metabolism</topic><topic>Kinetics</topic><topic>Phenylurea Compounds</topic><topic>Receptor, Cholecystokinin A</topic><topic>Receptors, Cholecystokinin - antagonists & inhibitors</topic><topic>Receptors, Cholecystokinin - physiology</topic><topic>Tetragastrin - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aarnisalo, Antti M</creatorcontrib><creatorcontrib>Vainio, Petri J</creatorcontrib><creatorcontrib>Männistö, Pekka T</creatorcontrib><creatorcontrib>Vasar, Eero</creatorcontrib><creatorcontrib>Tuominen, Raimo K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aarnisalo, Antti M</au><au>Vainio, Petri J</au><au>Männistö, Pekka T</au><au>Vasar, Eero</au><au>Tuominen, Raimo K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1996-09-02</date><risdate>1996</risdate><volume>7</volume><issue>13</issue><spage>2167</spage><epage>2170</epage><pages>2167-2170</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>8930982</pmid><doi>10.1097/00001756-199609020-00022</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adrenal Medulla - metabolism Adrenals. Interrenals Adrenomedullary hormones. Regulation Animals Benzodiazepinones - pharmacology Biological and medical sciences Cattle Cells, Cultured Ceruletide - pharmacology Chromaffin Cells - drug effects Chromaffin Cells - metabolism Devazepide Fundamental and applied biological sciences. Psychology Hormone Antagonists - pharmacology Inositol Phosphates - metabolism Kinetics Phenylurea Compounds Receptor, Cholecystokinin A Receptors, Cholecystokinin - antagonists & inhibitors Receptors, Cholecystokinin - physiology Tetragastrin - pharmacology Vertebrates: endocrinology |
| title | Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells |
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