Evidence for cholecystokininA receptors in bovine adrenal chromaffin cells

We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effe...

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Veröffentlicht in:Neuroreport 1996-09, Vol.7 (13), p.2167-2170
Hauptverfasser: Aarnisalo, Antti M, Vainio, Petri J, Männistö, Pekka T, Vasar, Eero, Tuominen, Raimo K
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Sprache:eng
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Zusammenfassung:We have studied a possible role of cholecystokinin (CCK) in regulating adrenal medullary function. Caerulein (10-10 M), a CCK receptor agonist, increased formation of inositol phosphates in primary cultured bovine adrenal medullary (BAM) chromaffin cells in a concentration-dependent manner. The effect of caerulein was antagonized by devazepide, a selective CCKA-receptor antagonist, but not by L-365.260, a selective CCKB-receptor antagonist. These results suggest that BAM cells possess functional CCK receptors of the CCKA-subtype. Stimulation of these receptors with caerulein activates a signal transduction pathway via phospholipase C. CCK may regulate catecholamine release in BAM cells.
ISSN:0959-4965
1473-558X
DOI:10.1097/00001756-199609020-00022