Surfactant stimulates prostaglandin E production in human amnion
Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of P...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1988-10, Vol.95 (10), p.1013-1017 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
| container_volume | 95 |
| creator | BERNAL, A. LÓPEZ NEWMAN, G. E. PHIZACKERLEY, P. J. R. TURNBULL, A. C. |
| description | Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of PGE from 3·8 (SD 2·9) to 5·4 (SD 2·5) pmol/mg dry weight/3 h (P |
| doi_str_mv | 10.1111/j.1471-0528.1988.tb06506.x |
| format | Article |
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LÓPEZ ; NEWMAN, G. E. ; PHIZACKERLEY, P. J. R. ; TURNBULL, A. C.</creator><creatorcontrib>BERNAL, A. LÓPEZ ; NEWMAN, G. E. ; PHIZACKERLEY, P. J. R. ; TURNBULL, A. C.</creatorcontrib><description>Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of PGE from 3·8 (SD 2·9) to 5·4 (SD 2·5) pmol/mg dry weight/3 h (P<0·01). Arachidonic acid accounted for 2% of the fatty acids of surfactant lecithin. These results show that surfactant has a stimulatory effect on amniotic PGE production and that it is an important source of arachidonic acid in amniotic fluid.</description><identifier>ISSN: 1470-0328</identifier><identifier>ISSN: 0306-5456</identifier><identifier>EISSN: 1471-0528</identifier><identifier>EISSN: 1365-215X</identifier><identifier>DOI: 10.1111/j.1471-0528.1988.tb06506.x</identifier><identifier>PMID: 3191038</identifier><identifier>CODEN: BJOGAS</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amnion - drug effects ; Amnion - metabolism ; Amniotic Fluid - metabolism ; Arachidonic Acids - metabolism ; Biological and medical sciences ; Cesarean Section ; Dose-Response Relationship, Drug ; Female ; Fetus - metabolism ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; In Vitro Techniques ; Pregnancy ; Pregnancy. Parturition. Lactation ; Prostaglandins E - biosynthesis ; Stimulation, Chemical ; Surface-Active Agents - pharmacology ; Time Factors ; Vertebrates: reproduction</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 1988-10, Vol.95 (10), p.1013-1017</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3993-4da75bffce14bc41626967b4d391c4e584c78a29a1261ba90136914cb4fa1d8b3</citedby><cites>FETCH-LOGICAL-c3993-4da75bffce14bc41626967b4d391c4e584c78a29a1261ba90136914cb4fa1d8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.1988.tb06506.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.1988.tb06506.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6753973$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3191038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BERNAL, A. LÓPEZ</creatorcontrib><creatorcontrib>NEWMAN, G. E.</creatorcontrib><creatorcontrib>PHIZACKERLEY, P. J. R.</creatorcontrib><creatorcontrib>TURNBULL, A. C.</creatorcontrib><title>Surfactant stimulates prostaglandin E production in human amnion</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>Br J Obstet Gynaecol</addtitle><description>Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of PGE from 3·8 (SD 2·9) to 5·4 (SD 2·5) pmol/mg dry weight/3 h (P<0·01). Arachidonic acid accounted for 2% of the fatty acids of surfactant lecithin. These results show that surfactant has a stimulatory effect on amniotic PGE production and that it is an important source of arachidonic acid in amniotic fluid.</description><subject>Amnion - drug effects</subject><subject>Amnion - metabolism</subject><subject>Amniotic Fluid - metabolism</subject><subject>Arachidonic Acids - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cesarean Section</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Fetus - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Prostaglandins E - biosynthesis</subject><subject>Stimulation, Chemical</subject><subject>Surface-Active Agents - pharmacology</subject><subject>Time Factors</subject><subject>Vertebrates: reproduction</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtOwzAQRS0EKqXwCUgRQuwSPLGT2Gx4VOWlSl0Aa2viOJAqSUuciPbvcWjUPd7Yo3tnfOcQcgE0AHeulwHwBHwahSIAKUTQpjSOaBxsDsh4Lx3-valPWSiOyYm1S0ohDikbkREDCZSJMbl765ocdYt169m2qLoSW2O9dbOyLX6WWGdF7c36Out0W6xqz9VfXYW1h1Xt6lNylGNpzdlwT8jH4-x9-uzPF08v0_u5r5mUzOcZJlGa59oATzV3OWIZJynPmATNTSS4TgSGEiGMIUVJgcUSuE55jpCJlE3I1W6ui_LdGduqqrDalC6iWXVWJSLiLARwxpudUbsdbGNytW6KCputAqp6fGqpekaqZ6R6fGrApzau-Xz4pUsrk-1bB15Ovxx0tBrLvMFaF3Zvi5OIyYQ52-3O9lOUZvuPAOrhdQFud_YLLi6MkA</recordid><startdate>198810</startdate><enddate>198810</enddate><creator>BERNAL, A. LÓPEZ</creator><creator>NEWMAN, G. E.</creator><creator>PHIZACKERLEY, P. J. R.</creator><creator>TURNBULL, A. C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198810</creationdate><title>Surfactant stimulates prostaglandin E production in human amnion</title><author>BERNAL, A. LÓPEZ ; NEWMAN, G. E. ; PHIZACKERLEY, P. J. R. ; TURNBULL, A. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3993-4da75bffce14bc41626967b4d391c4e584c78a29a1261ba90136914cb4fa1d8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amnion - drug effects</topic><topic>Amnion - metabolism</topic><topic>Amniotic Fluid - metabolism</topic><topic>Arachidonic Acids - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cesarean Section</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Fetus - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Prostaglandins E - biosynthesis</topic><topic>Stimulation, Chemical</topic><topic>Surface-Active Agents - pharmacology</topic><topic>Time Factors</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BERNAL, A. LÓPEZ</creatorcontrib><creatorcontrib>NEWMAN, G. E.</creatorcontrib><creatorcontrib>PHIZACKERLEY, P. J. R.</creatorcontrib><creatorcontrib>TURNBULL, A. C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BERNAL, A. LÓPEZ</au><au>NEWMAN, G. E.</au><au>PHIZACKERLEY, P. J. R.</au><au>TURNBULL, A. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surfactant stimulates prostaglandin E production in human amnion</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1988-10</date><risdate>1988</risdate><volume>95</volume><issue>10</issue><spage>1013</spage><epage>1017</epage><pages>1013-1017</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of PGE from 3·8 (SD 2·9) to 5·4 (SD 2·5) pmol/mg dry weight/3 h (P<0·01). Arachidonic acid accounted for 2% of the fatty acids of surfactant lecithin. These results show that surfactant has a stimulatory effect on amniotic PGE production and that it is an important source of arachidonic acid in amniotic fluid.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3191038</pmid><doi>10.1111/j.1471-0528.1988.tb06506.x</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 1988-10, Vol.95 (10), p.1013-1017 |
| issn | 1470-0328 0306-5456 1471-0528 1365-215X |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Amnion - drug effects Amnion - metabolism Amniotic Fluid - metabolism Arachidonic Acids - metabolism Biological and medical sciences Cesarean Section Dose-Response Relationship, Drug Female Fetus - metabolism Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans In Vitro Techniques Pregnancy Pregnancy. Parturition. Lactation Prostaglandins E - biosynthesis Stimulation, Chemical Surface-Active Agents - pharmacology Time Factors Vertebrates: reproduction |
| title | Surfactant stimulates prostaglandin E production in human amnion |
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