Surfactant stimulates prostaglandin E production in human amnion

Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of P...

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Veröffentlicht in:	BJOG : an international journal of obstetrics and gynaecology 1988-10, Vol.95 (10), p.1013-1017
Hauptverfasser:	BERNAL, A. LÓPEZ, NEWMAN, G. E., PHIZACKERLEY, P. J. R., TURNBULL, A. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnion - drug effects Amnion - metabolism Amniotic Fluid - metabolism Arachidonic Acids - metabolism Biological and medical sciences Cesarean Section Dose-Response Relationship, Drug Female Fetus - metabolism Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans In Vitro Techniques Pregnancy Pregnancy. Parturition. Lactation Prostaglandins E - biosynthesis Stimulation, Chemical Surface-Active Agents - pharmacology Time Factors Vertebrates: reproduction
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Zusammenfassung:	Discs of human amnion prepared from nine women delivered by elective caesarean section at term were incubated with and without purified human amniotic fluid surfactant (9 μg lipid P/ml), and the output of prostaglandin E (PGE) was estimated by radioimmunoassay. Surfactant stimulated the release of PGE from 3·8 (SD 2·9) to 5·4 (SD 2·5) pmol/mg dry weight/3 h (P
ISSN:	1470-0328 0306-5456 1471-0528 1365-215X
DOI:	10.1111/j.1471-0528.1988.tb06506.x