Design, Synthesis, and Evolution of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors: P1-Argininal Derivatives Incorporating P3-P4 Lactam Sulfonamide Moieties

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Veröffentlicht in:	Journal of medicinal chemistry 1996-11, Vol.39 (23), p.4531-4536
Hauptverfasser:	Semple, J. Edward, Rowley, David C, Brunck, Terence K, Ha-Uong, Theresa, Minami, Nathaniel K, Owens, Timothy D, Tamura, Susan Y, Goldman, Erick A, Siev, Daniel V, Ardecky, Robert J, Carpenter, Stephen H, Ge, Yu, Richard, Brigitte M, Nolan, Thomas G, Håkanson, Kjell, Tulinsky, Al, Nutt, Ruth F, Ripka, William C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithrombins - chemical synthesis Antithrombins - chemistry Antithrombins - pharmacokinetics Arginine - chemistry Biological and medical sciences Biological Availability Blood. Blood coagulation. Reticuloendothelial system Dogs Drug Design Lactams - chemistry Medical sciences Molecular Structure Pharmacology. Drug treatments Structure-Activity Relationship
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