Major structural polypeptides of retrovirus produced by a Suncus murinus mammary tumor cell line and type D retrovirus share interspecies antigenic determinants

Major structural polypeptides of retrovirus produced by a Suncus murinus mammary tumor cell line and type D retrovirus share interspecies antigenic determinants

Constitutive polypeptides of retrovirus produced by a Suncus murinus mammary tumor cell line (Sm-MTV) were characterized by immunofluorescence and immunoblotting. The major structural polypeptide of Sm-MTV, molecular weight 44 43 K , immunologically cross reacted with the structural polypeptides of...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1988-11, Vol.167 (1), p.314-317
Hauptverfasser: Aoyama, Atsuko, Saga, Shinsuke, Nagayoshl, Shoichi, Yokoi, Toyoharu, Malavasi, Jollyanna, Takenaka, Tokuya, Tsutsui, Yoshihiro, Hoshino, Munemitsu
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigens, Viral - immunology
Cross Reactions
Electrophoresis, Polyacrylamide Gel
Epitopes - immunology
Female
Fluorescent Antibody Technique
Immunoblotting
Immunoenzyme Techniques
Mammary Glands, Animal
Neoplasms - veterinary
Peptides - immunology
Retroviridae - immunology
Retroviridae Proteins - immunology
Shrews
Tumor Cells, Cultured
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Zusammenfassung:Constitutive polypeptides of retrovirus produced by a Suncus murinus mammary tumor cell line (Sm-MTV) were characterized by immunofluorescence and immunoblotting. The major structural polypeptide of Sm-MTV, molecular weight 44 43 K , immunologically cross reacted with the structural polypeptides of Mason-Pfizer monkey virus (MPMV) (molecular weights 27K and 12 10 K ). Sm-MTV constitutive polypeptides did not show antigenic relatedness with those of the following mammalian retroviruses: murine mammary tumor virus, Rausher murine leukemia virus, Molony murine leukemia virus, Osborn-Mendel rat leukemia virus, feline leukemia virus, RD114 virus, simian sarcoma virus 1, and human T-cell leukemia virus type I. Among the Sm-MTV structural polypeptides, those with molecular weights of 72 69 K and 47K were glycosylated.
ISSN:0042-6822
1096-0341
DOI:10.1016/0042-6822(88)90088-8