Further studies on opioids and hibernation: Delta opioid receptor ligand selectively induced hibernation in summer-active ground squirrels
To examine the possible involvement of multiple opioid receptors in animal hibernation, we infused opioids selective for mu , kappa , and delta opioid receptors into summer-active ground squirrels ( Citellus tridecemlineatus ). The effects of those opioid treatments on the hibernation induced by HIT...
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Veröffentlicht in: | Life sciences (1973) 1988, Vol.43 (19), p.1565-1574 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To examine the possible involvement of multiple opioid receptors in animal hibernation, we infused opioids selective for
mu
,
kappa
, and
delta
opioid receptors into summer-active ground squirrels (
Citellus tridecemlineatus
). The effects of those opioid treatments on the hibernation induced by HIT (Hibernation Induction Trigger) were also examined.
Mu
opioids morphine (1.50 mg/kg/day) and morphiceptin (0.82 mg/kg/day) and
kappa
opioid peptide dynorphin A (0.82 mg/kg/day) did not induce hibernation. On the contrary, morphine, morphiceptin and dynorphin A antagonized HIT-induced hibernation in summer-active ground squirrels. Infusion of
delta
opioid DADLE (D-Ala
2-D-Leu
5 enkephalin; 1.50 mg/kg/day), however, induced summer hibernation in a manner comparable to that induced by HIT. It is concluded therefore that
delta
opioid receptor and its ligand may be intimately involved in animal hibernation. In view of the fact that HIT was obtained from winter hibernating animals and might therefore be responsible for natural hibernation, our results also suggest that naturally occuring
mu
and
kappa
opioids may play an important role in the arousal state of hibernation. |
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ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/0024-3205(88)90406-7 |