SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF N-ACYL VANCOMYCINS

Several glycopeptides containing N-acyl groups have been isolated recently. We undertook the synthesis of N-acyl vancomycins, using the active ester method. The in vitro and in vivo antibacterial activity were evaluated, and structure-activity relationship of this series of semisynthetic vancomycins...

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Veröffentlicht in:	Journal of antibiotics 1988/10/25, Vol.41(10), pp.1430-1438
Hauptverfasser:	NAGARAJAN, R., SCHABEL, A. A., OCCOLOWITZ, J. L., COUNTER, F. T., OTT, J. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Infections - drug therapy Chemical Phenomena Chemistry Exact sciences and technology In Vitro Techniques Mice Microbial Sensitivity Tests Organic chemistry Peptides Preparations and properties Structure-Activity Relationship Vancomycin - analogs & derivatives Vancomycin - chemical synthesis
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Beschreibung
Zusammenfassung:	Several glycopeptides containing N-acyl groups have been isolated recently. We undertook the synthesis of N-acyl vancomycins, using the active ester method. The in vitro and in vivo antibacterial activity were evaluated, and structure-activity relationship of this series of semisynthetic vancomycins is discussed.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.41.1430