The Effect of 2, 4-Dichlorophenol on Lipid Peroxidation in Tissues of Guinea Pigs with Different Ascorbic Acid Intake

Chlorinated phenols are widely used in the manufacture of biocides and wood preservatives. 2, 4-dichlorophenol administered perorally 3 times a week at a dose of 40 mg in 0.2ml of olive oil per kg of body weight to guinea pigs increased lipid peroxidation in liver and adrenals after 2 weeks of treatment. A high intake of ascorbic acid (50mg/animal/day) significantly decreased lipid peroxidation in the liver of 2, 4-dichlorophenol treated guinea pigs in comparison to guinea pigs with low ascorbic acid intake (2mg/animal/day). 2, 4-dichlorophenol accumulation was also decreased in the liver of animals with high ascorbic acid intake. Increased daily intake of vitamin C to persons involved in production and use of chlorophenoxy herbicides is recommended.