Zinc status of children with sickle cell disease: Relationship to poor growth

Zinc status of children with sickle cell disease: Relationship to poor growth

We examined the zinc status of 80 children with sickle cell disease (SCD) and 44 disease‐free sibling controls aged 3 to 18 years. For both patients and controls, variations in serum zinc by age, type of hemoglobinopathy, and growth status were measured. The mean serum zinc concentration of patients...

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Veröffentlicht in:American journal of hematology 1988-10, Vol.29 (2), p.67-73
Hauptverfasser: Phebus, Carol K., Maciak, Barbara J., Gloninger, Margaret F., Paul, Harbajan S.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Alkaline Phosphatase - blood
Anemia, Sickle Cell - metabolism
Blood Proteins - analysis
Child
Child Development
Child, Preschool
Diet
Female
hemolytic anemia
Humans
Male
Retinol-Binding Proteins - blood
Serum Albumin - analysis
Sickle Cell Trait - blood
Sickle Cell Trait - metabolism
Sickle Cell Trait - physiopathology
Zinc - blood
Zinc - metabolism
zinc deficiency
zinc proteins
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Zusammenfassung:We examined the zinc status of 80 children with sickle cell disease (SCD) and 44 disease‐free sibling controls aged 3 to 18 years. For both patients and controls, variations in serum zinc by age, type of hemoglobinopathy, and growth status were measured. The mean serum zinc concentration of patients was significantly lower than for controls (77.8 ± 9.9 vs. 82.2 ± 9.8 μg/dl, mean ± 1SD, P < .05). Serum levels of alkaline phosphatase (AP) and retinol‐binding protein (RBP), two zinc‐dependent proteins, were also lower among patients (AP: 171 ± 66 vs. 243 ± 97 IU/L, P < .001; RBP: 1.92 ± .9 vs. 2.77 ± .9 mg/dl, P
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.2830290203