Detection of a soluble form of the human adhesion receptor lymphocyte function-associated antigen-3 (LFA-3) in patients with chronic liver disease

Background/Aims: Multiple immune functions, such as cytotoxic reactions, B cell differentiation, and monocyte activation, are mediated via the adhesion receptor/ligand pairs CD2/lymphocyte function-associated antigen(LFA)-3 and LFA-1/intercellular adhesion molecule (ICAM)-1. Since soluble forms of L...

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Veröffentlicht in:Journal of hepatology 1996-10, Vol.25 (4), p.465-473
Hauptverfasser: Hoffmann, Jörg C., Bahr, Matthias J., Tietge, Uwe J.F., Braunstein, Jutta, Bayer, Bettina, Böker, Klaus H.W., Manns, Michael P.
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Sprache:eng
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Zusammenfassung:Background/Aims: Multiple immune functions, such as cytotoxic reactions, B cell differentiation, and monocyte activation, are mediated via the adhesion receptor/ligand pairs CD2/lymphocyte function-associated antigen(LFA)-3 and LFA-1/intercellular adhesion molecule (ICAM)-1. Since soluble forms of LFA-3 (sLFA-3) and ICAM-1 (sICAM-1) can interfere with these functions, we asked whether increased levels of sLFA-3 can be found in patients with different forms of chronic liver disease and/or hepatocellular carcinoma. Methods: sLFA-3 was measured in sera from 84 patients with chronic liver disease (39 with chronic viral liver disease, 30 with autoimmune liver disease, 12 with alcoholic cirrhosis, 3 with other causes of cirrhosis), 24 patients with hepatocellular carcinoma (15 with and 9 without cirrhosis), and 61 normal controls. From 36 of the patients with liver cirrhosis, arterial and hepatic venous serum samples were simultaneously obtained and tested for sLFA-3 and sICAM-1. Results: In comparison to controls, sLFA-3 levels were elevated in patients with liver cirrhosis due to autoimmune liver disease ( p
ISSN:0168-8278
1600-0641
DOI:10.1016/S0168-8278(96)80205-4