LOGRANK, PLAY THE WINNER, POWER AND ETHICS

LOGRANK, PLAY THE WINNER, POWER AND ETHICS

We show by simulation and numerical integration techniques that power is largely unaffected by play the winner strategies in a typical chronic disease mortality trial utilizing the logrank test. This raises the issue of the ethics of equal allocation in such a setting.

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Veröffentlicht in:Statistics in medicine 1996-10, Vol.15 (20), p.2135-2142
Hauptverfasser: HALLSTROM, AL, BROOKS, MARIA MORI, PECKOVA, MONIKA
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Arrhythmia Agents - therapeutic use
Biological and medical sciences
Computerized, statistical medical data processing and models in biomedicine
Defibrillators, Implantable
Ethics, Medical
Humans
Medical sciences
Medical statistics
Models, Statistical
Patient Selection
Power (Psychology)
Randomized Controlled Trials as Topic - methods
Survival Analysis
Tachycardia, Ventricular - mortality
Tachycardia, Ventricular - therapy
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Beschreibung
Zusammenfassung:We show by simulation and numerical integration techniques that power is largely unaffected by play the winner strategies in a typical chronic disease mortality trial utilizing the logrank test. This raises the issue of the ethics of equal allocation in such a setting.
ISSN:0277-6715
1097-0258
DOI:10.1002/(SICI)1097-0258(19961030)15:20<2135::AID-SIM355>3.0.CO;2-G