Effect of chronic treatment with octreotide nasal powder on serum levels of growth hormone, insulin-like growth factor I, insulin-like growth factor binding proteins 1 and 3 in acromegalic patients
Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initia...
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Veröffentlicht in: | Journal of endocrinological investigation 1996-09, Vol.19 (8), p.548-555 |
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description | Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 micrograms/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-I, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-I serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-I and insulin. Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-I and IGFBP-1. Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 micrograms/l in 7/8 patients and IGF-I levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-I, GH and IGFBP-3, IGF-I and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-I. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent. |
doi_str_mv | 10.1007/BF03349015 |
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G ; PORCU, L ; DANESI, L ; DELITALA, G ; CAVAGNINI, F</creator><creatorcontrib>INVITTI, C ; FATTI, L ; CAMBONI, M. G ; PORCU, L ; DANESI, L ; DELITALA, G ; CAVAGNINI, F</creatorcontrib><description>Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 micrograms/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-I, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-I serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-I and insulin. Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-I and IGFBP-1. Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 micrograms/l in 7/8 patients and IGF-I levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-I, GH and IGFBP-3, IGF-I and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-I. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03349015</identifier><identifier>PMID: 8905479</identifier><identifier>CODEN: JEIND7</identifier><language>eng</language><publisher>Milano: Kurtis</publisher><subject>Acromegaly - blood ; Acromegaly - drug therapy ; Administration, Intranasal ; Adult ; Aged ; Biological and medical sciences ; Drug Administration Schedule ; Drug Delivery Systems ; Evaluation Studies as Topic ; Female ; Hormones - therapeutic use ; Hormones. Endocrine system ; Human Growth Hormone - blood ; Humans ; Insulin-Like Growth Factor Binding Protein 1 - blood ; Insulin-Like Growth Factor Binding Protein 3 - blood ; Insulin-Like Growth Factor Binding Proteins - blood ; Insulin-Like Growth Factor I - metabolism ; Male ; Medical sciences ; Middle Aged ; Octreotide - therapeutic use ; Pharmacology. Drug treatments ; Powders</subject><ispartof>Journal of endocrinological investigation, 1996-09, Vol.19 (8), p.548-555</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c243t-7d0dce9bae3d7f4b6653c4b14f14c56004b38d2d7f4315ec89b4c73b2638edb03</citedby><cites>FETCH-LOGICAL-c243t-7d0dce9bae3d7f4b6653c4b14f14c56004b38d2d7f4315ec89b4c73b2638edb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3251724$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8905479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INVITTI, C</creatorcontrib><creatorcontrib>FATTI, L</creatorcontrib><creatorcontrib>CAMBONI, M. G</creatorcontrib><creatorcontrib>PORCU, L</creatorcontrib><creatorcontrib>DANESI, L</creatorcontrib><creatorcontrib>DELITALA, G</creatorcontrib><creatorcontrib>CAVAGNINI, F</creatorcontrib><title>Effect of chronic treatment with octreotide nasal powder on serum levels of growth hormone, insulin-like growth factor I, insulin-like growth factor binding proteins 1 and 3 in acromegalic patients</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 micrograms/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-I, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-I serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-I and insulin. Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-I and IGFBP-1. Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 micrograms/l in 7/8 patients and IGF-I levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-I, GH and IGFBP-3, IGF-I and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-I. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent.</description><subject>Acromegaly - blood</subject><subject>Acromegaly - drug therapy</subject><subject>Administration, Intranasal</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Drug Administration Schedule</subject><subject>Drug Delivery Systems</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Hormones - therapeutic use</subject><subject>Hormones. Endocrine system</subject><subject>Human Growth Hormone - blood</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor Binding Protein 1 - blood</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor Binding Proteins - blood</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Octreotide - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Powders</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb1uFDEUhS0ECptAQ4_kAlEgBuyxZzwuIUogUiQaqEf-ud41eOzF9mTFA_JeeJUldFRX8vnuucc6CL2g5B0lRLz_eE0Y45LQ4RHaUNGTbmLT-BhtCJO040SKp-i8lO-EMMEmcYbOJkkGLuQG_b5yDkzFyWGzyyl6g2sGVReIFR983eFk2kOq3gKOqqiA9-lgIeMUcYG8LjjAHYRydNjmdGgbu5SXFOEt9rGswccu-B_wV3TK1JTxzX9V7aP1cYv3OVVoHKZYRYtZ28HK5LTAVoUWda-qb0HLM_TEqVDg-WleoG_XV18vP3e3Xz7dXH647UzPWe2EJdaA1AqYFY7rcRyY4ZpyR7kZRkK4ZpPtjxqjA5hJam4E0_3IJrCasAv0-t63Bfu5Qqnz4ouBEFSEtJZZTAMVUh7BN_dgC1tKBjfvs19U_jVTMh87m_911uCXJ9dVL2Af0FNJTX910lUxKrisovHlAWN9O9r-9wf086JP</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>INVITTI, C</creator><creator>FATTI, L</creator><creator>CAMBONI, M. 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G ; PORCU, L ; DANESI, L ; DELITALA, G ; CAVAGNINI, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c243t-7d0dce9bae3d7f4b6653c4b14f14c56004b38d2d7f4315ec89b4c73b2638edb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acromegaly - blood</topic><topic>Acromegaly - drug therapy</topic><topic>Administration, Intranasal</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Drug Administration Schedule</topic><topic>Drug Delivery Systems</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Hormones - therapeutic use</topic><topic>Hormones. Endocrine system</topic><topic>Human Growth Hormone - blood</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor Binding Protein 1 - blood</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor Binding Proteins - blood</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Octreotide - therapeutic use</topic><topic>Pharmacology. Drug treatments</topic><topic>Powders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INVITTI, C</creatorcontrib><creatorcontrib>FATTI, L</creatorcontrib><creatorcontrib>CAMBONI, M. G</creatorcontrib><creatorcontrib>PORCU, L</creatorcontrib><creatorcontrib>DANESI, L</creatorcontrib><creatorcontrib>DELITALA, G</creatorcontrib><creatorcontrib>CAVAGNINI, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>INVITTI, C</au><au>FATTI, L</au><au>CAMBONI, M. G</au><au>PORCU, L</au><au>DANESI, L</au><au>DELITALA, G</au><au>CAVAGNINI, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chronic treatment with octreotide nasal powder on serum levels of growth hormone, insulin-like growth factor I, insulin-like growth factor binding proteins 1 and 3 in acromegalic patients</atitle><jtitle>Journal of endocrinological investigation</jtitle><addtitle>J Endocrinol Invest</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>19</volume><issue>8</issue><spage>548</spage><epage>555</epage><pages>548-555</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><coden>JEIND7</coden><abstract>Octreotide nasal powder is a delivery system of the somatostatin analogue developed to overcome the inconvenience of repeated subcutaneous administrations. Eight patients with clinically active acromegaly were treated for three months with octreotide nasal powder which was administered at the initial dosage of 0.125 mg tid, doubling the dosage up to 2 mg tid in order to obtain a mean GH value below 5 micrograms/l during 8 daytime hours. In 4 of these patients, treatment was prolonged till the sixth month. Blood samples were taken on days 15, 29, 43, 55, 90, 120, 150, 180 for GH, IGF-I, IGFBP-3, IGFBP-1 and insulin measurements. Before treatment, mean daytime GH and morning IGF-I serum levels were both increased but not correlated with each other. Serum IGFBP-3 levels were higher than normal and positively correlated with those of GH, IGF-I and insulin. Insulin levels were elevated and positively correlated with those of GH but not with those of IGF-I and IGFBP-1. Serum IGFBP-1 levels were in the low normal range and not correlated with any of the other parameters. Treatment with octreotide nasal powder induced in all patients a marked decrease of GH which lowered below 5 micrograms/l in 7/8 patients and IGF-I levels, which fell within the normal range in 1 patient. Serum IGFBP-3 and insulin concentrations decreased by 26% and 71%, respectively, and those of IGFBP-1 underwent an only transient increase in 5/8 patients. Opposite changes of insulin and IGFBP-1 levels, with a decrease of the former followed by an increase of the latter were noted during the 8 hours following an octreotide nasal insufflation. During chronic octreotide treatment, positive correlations were found between GH and IGF-I, GH and IGFBP-3, IGF-I and IGFBP-3, insulin and IGFBP-3 and insulin and IGF-I. An improvement of the clinical picture was registered in all patients after a few days of octreotide nasal powder administration. Treatment was well tolerated, with only mild side effects and no significant changes in the nasal mucosa, and the patients' compliance was excellent.</abstract><cop>Milano</cop><pub>Kurtis</pub><pmid>8905479</pmid><doi>10.1007/BF03349015</doi><tpages>8</tpages></addata></record> |
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subjects | Acromegaly - blood Acromegaly - drug therapy Administration, Intranasal Adult Aged Biological and medical sciences Drug Administration Schedule Drug Delivery Systems Evaluation Studies as Topic Female Hormones - therapeutic use Hormones. Endocrine system Human Growth Hormone - blood Humans Insulin-Like Growth Factor Binding Protein 1 - blood Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor I - metabolism Male Medical sciences Middle Aged Octreotide - therapeutic use Pharmacology. Drug treatments Powders |
title | Effect of chronic treatment with octreotide nasal powder on serum levels of growth hormone, insulin-like growth factor I, insulin-like growth factor binding proteins 1 and 3 in acromegalic patients |
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