Photosensitization by anticancer agents 21: New perylene- and aminonaphthoquinones

Photosensitization by anticancer agents 21: New perylene- and aminonaphthoquinones

Hypocrellins are under intensive investigation as photosensitizing agents for photodynamic therapy (PDT). A recent advance in the synthesis of hypocrellin congeners resulted in the production of an amino-substituted hypocrellin-B, and its “half chromophore.” Both compounds exhibit stronger red light...

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Veröffentlicht in:Free radical biology & medicine 1996, Vol.20 (4), p.589-593
Hauptverfasser: Diwu, Zhenjun J., Haugland, Richard P., Liu, Jixiang, Lown, J.William, Miller, Gerald G., Moore, Ronald B., Brown, Kevin, Tulip, John, McPhee, Malcolm S.
Format: Artikel
Sprache:eng
Schlagworte:
Aminonaphthoquinones
Animals
Free radicals
Hypocrellins
Mice
Molecular Structure
Neoplasms, Experimental - drug therapy
Perylene - analogs & derivatives
Perylene - therapeutic use
Perylenequinones
Photochemotherapy
Photodynamic therapy
Photosensitizers
Quinones - therapeutic use
Tumor Cells, Cultured
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Zusammenfassung:Hypocrellins are under intensive investigation as photosensitizing agents for photodynamic therapy (PDT). A recent advance in the synthesis of hypocrellin congeners resulted in the production of an amino-substituted hypocrellin-B, and its “half chromophore.” Both compounds exhibit stronger red light absorption than previously reported hypocrellins, and, therefore, merit investigation as photosensitizers.
ISSN:0891-5849
1873-4596
DOI:10.1016/0891-5849(95)02061-6