Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium
Objective. To examine the expression of sex steroid receptors (ER: estrogen receptor; PR: progesterone receptor) in the postmenopausal endometrium (PMEM) and the relationship to clinical data for studying its characters. Methods. The immunohistochemical reactivity of the PMEM was studied using monoc...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 1996-08, Vol.75 (8), p.702-706 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
| container_volume | 75 |
| creator | Koshiyama, Masafumi Yoshida, Masumi Takemura, Maki Yura, Yasuichirou Matsushita, Katsuko Hayashi, Michiharu Tauchi, Kunihiko Konishi, Ikuo Mori, Takahide |
| description | Objective. To examine the expression of sex steroid receptors (ER: estrogen receptor; PR: progesterone receptor) in the postmenopausal endometrium (PMEM) and the relationship to clinical data for studying its characters.
Methods. The immunohistochemical reactivity of the PMEM was studied using monoclonal antibodies against ER and PR, in 33 postmenopausal patients.
Results. The endometrium was thicker in patients who were postmenopausal for 1 to 10 years (1.48±1.31mm) than in patients who were postmenopausal for more than 10 years (0.79 ± 0.37mm) (p |
| doi_str_mv | 10.3109/00016349609065730 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78511938</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78511938</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5283-6c5ec62b8f9ad1cd76a1ed9d5ca86244477a5821542837085b666658a9571b923</originalsourceid><addsrcrecordid>eNqFkcGL1DAUxoMo6-zqH-BB6EG8VZOmSVM8LYs7s7i4IKMeQ5q-2qxNUpMWd07-66ZMGQRBcwkv3-_78vKC0AuC31CC67cYY8JpWXNcY84qih-hDeEY57gkxWO0WfR8AZ6i8xjvU1VUpThDZyLxqdqgXzfWzs73Jk5e92CNVkOmnBoO0cTMd1mblGCaeTLeLTWk0n8DlwXQME4-xIS32bgcxgmCd_CHZFw29ZCNPk4WnB_VHFM-uNZbSLGzfYaedGqI8HzdL9Dn6_f7q11-e7e9ubq8zTUrBM25ZqB50YiuVi3RbcUVgbZumVaCF2VZVpVioiCsTHSFBWt4WkyomlWkqQt6gV4fc1OjP-bUqbQmahgG5cDPUVaCEVJTkUByBHXwMQbo5BiMVeEgCZbL0OVfQ0-el2v43FhoT451ykl_teoqpvl2QTlt4gmjBRO0pAnjR-ynGeDw_3vl5d2W1Hgx5kdj-it4OBlV-C55RSsmv37cyv3uC_7w6Xovd4l_t_Ku88GqHtQw9VoFkPd-Dun34z9e-xtHZrzs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78511938</pqid></control><display><type>article</type><title>Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Koshiyama, Masafumi ; Yoshida, Masumi ; Takemura, Maki ; Yura, Yasuichirou ; Matsushita, Katsuko ; Hayashi, Michiharu ; Tauchi, Kunihiko ; Konishi, Ikuo ; Mori, Takahide</creator><creatorcontrib>Koshiyama, Masafumi ; Yoshida, Masumi ; Takemura, Maki ; Yura, Yasuichirou ; Matsushita, Katsuko ; Hayashi, Michiharu ; Tauchi, Kunihiko ; Konishi, Ikuo ; Mori, Takahide</creatorcontrib><description>Objective. To examine the expression of sex steroid receptors (ER: estrogen receptor; PR: progesterone receptor) in the postmenopausal endometrium (PMEM) and the relationship to clinical data for studying its characters.
Methods. The immunohistochemical reactivity of the PMEM was studied using monoclonal antibodies against ER and PR, in 33 postmenopausal patients.
Results. The endometrium was thicker in patients who were postmenopausal for 1 to 10 years (1.48±1.31mm) than in patients who were postmenopausal for more than 10 years (0.79 ± 0.37mm) (p<0.05). Among the 33 postmenopausal endometrial samples, ER positivity was found in the glands in 26 cases (78.8%) and PR positivity was detected in 18 cases (54.5%). The average age of the patients with ER positive reactivity in the glands (61.69±7.26 years) was significantly lower than that of the patients with ER negative reactivity (66.00±3.56 years) (p<0.05). Furthermore, the endometrial thickness of the patients with ER or PR positive reactivity in the glands (1.24± 1.09mm and 1.47±1.20mm, respectively) was significantly greater than that of the patients with ER or PR negative reactivity (0.67± 0.26mm and 0.70± 0.40mm, respectively) (p<0.05).
Conclusion. ER in the glands of the PMEM was determined to decrease gradually with increased aging. The presence of ER and PR in the gland cells seemed likely to determine the thickness of the PMEM.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.3109/00016349609065730</identifier><identifier>PMID: 8906001</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>Aged ; Aged, 80 and over ; aging ; Aging - physiology ; Antibodies, Monoclonal ; Biological and medical sciences ; endometrial thickness ; Endometrium - anatomy & histology ; Endometrium - chemistry ; estrogen receptor ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; Immunohistochemistry ; Mammalian female genital system ; Middle Aged ; postmenopausal endometrium ; Postmenopause - metabolism ; progesterone receptor ; Receptors, Estrogen - analysis ; Receptors, Progesterone - analysis ; Vertebrates: reproduction</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 1996-08, Vol.75 (8), p.702-706</ispartof><rights>1996 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1996</rights><rights>1996 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5283-6c5ec62b8f9ad1cd76a1ed9d5ca86244477a5821542837085b666658a9571b923</citedby><cites>FETCH-LOGICAL-c5283-6c5ec62b8f9ad1cd76a1ed9d5ca86244477a5821542837085b666658a9571b923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.3109%2F00016349609065730$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.3109%2F00016349609065730$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3258343$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8906001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koshiyama, Masafumi</creatorcontrib><creatorcontrib>Yoshida, Masumi</creatorcontrib><creatorcontrib>Takemura, Maki</creatorcontrib><creatorcontrib>Yura, Yasuichirou</creatorcontrib><creatorcontrib>Matsushita, Katsuko</creatorcontrib><creatorcontrib>Hayashi, Michiharu</creatorcontrib><creatorcontrib>Tauchi, Kunihiko</creatorcontrib><creatorcontrib>Konishi, Ikuo</creatorcontrib><creatorcontrib>Mori, Takahide</creatorcontrib><title>Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Objective. To examine the expression of sex steroid receptors (ER: estrogen receptor; PR: progesterone receptor) in the postmenopausal endometrium (PMEM) and the relationship to clinical data for studying its characters.
Methods. The immunohistochemical reactivity of the PMEM was studied using monoclonal antibodies against ER and PR, in 33 postmenopausal patients.
Results. The endometrium was thicker in patients who were postmenopausal for 1 to 10 years (1.48±1.31mm) than in patients who were postmenopausal for more than 10 years (0.79 ± 0.37mm) (p<0.05). Among the 33 postmenopausal endometrial samples, ER positivity was found in the glands in 26 cases (78.8%) and PR positivity was detected in 18 cases (54.5%). The average age of the patients with ER positive reactivity in the glands (61.69±7.26 years) was significantly lower than that of the patients with ER negative reactivity (66.00±3.56 years) (p<0.05). Furthermore, the endometrial thickness of the patients with ER or PR positive reactivity in the glands (1.24± 1.09mm and 1.47±1.20mm, respectively) was significantly greater than that of the patients with ER or PR negative reactivity (0.67± 0.26mm and 0.70± 0.40mm, respectively) (p<0.05).
Conclusion. ER in the glands of the PMEM was determined to decrease gradually with increased aging. The presence of ER and PR in the gland cells seemed likely to determine the thickness of the PMEM.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>aging</subject><subject>Aging - physiology</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>endometrial thickness</subject><subject>Endometrium - anatomy & histology</subject><subject>Endometrium - chemistry</subject><subject>estrogen receptor</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Mammalian female genital system</subject><subject>Middle Aged</subject><subject>postmenopausal endometrium</subject><subject>Postmenopause - metabolism</subject><subject>progesterone receptor</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Vertebrates: reproduction</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGL1DAUxoMo6-zqH-BB6EG8VZOmSVM8LYs7s7i4IKMeQ5q-2qxNUpMWd07-66ZMGQRBcwkv3-_78vKC0AuC31CC67cYY8JpWXNcY84qih-hDeEY57gkxWO0WfR8AZ6i8xjvU1VUpThDZyLxqdqgXzfWzs73Jk5e92CNVkOmnBoO0cTMd1mblGCaeTLeLTWk0n8DlwXQME4-xIS32bgcxgmCd_CHZFw29ZCNPk4WnB_VHFM-uNZbSLGzfYaedGqI8HzdL9Dn6_f7q11-e7e9ubq8zTUrBM25ZqB50YiuVi3RbcUVgbZumVaCF2VZVpVioiCsTHSFBWt4WkyomlWkqQt6gV4fc1OjP-bUqbQmahgG5cDPUVaCEVJTkUByBHXwMQbo5BiMVeEgCZbL0OVfQ0-el2v43FhoT451ykl_teoqpvl2QTlt4gmjBRO0pAnjR-ynGeDw_3vl5d2W1Hgx5kdj-it4OBlV-C55RSsmv37cyv3uC_7w6Xovd4l_t_Ku88GqHtQw9VoFkPd-Dun34z9e-xtHZrzs</recordid><startdate>199608</startdate><enddate>199608</enddate><creator>Koshiyama, Masafumi</creator><creator>Yoshida, Masumi</creator><creator>Takemura, Maki</creator><creator>Yura, Yasuichirou</creator><creator>Matsushita, Katsuko</creator><creator>Hayashi, Michiharu</creator><creator>Tauchi, Kunihiko</creator><creator>Konishi, Ikuo</creator><creator>Mori, Takahide</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199608</creationdate><title>Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium</title><author>Koshiyama, Masafumi ; Yoshida, Masumi ; Takemura, Maki ; Yura, Yasuichirou ; Matsushita, Katsuko ; Hayashi, Michiharu ; Tauchi, Kunihiko ; Konishi, Ikuo ; Mori, Takahide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5283-6c5ec62b8f9ad1cd76a1ed9d5ca86244477a5821542837085b666658a9571b923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>aging</topic><topic>Aging - physiology</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>endometrial thickness</topic><topic>Endometrium - anatomy & histology</topic><topic>Endometrium - chemistry</topic><topic>estrogen receptor</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Mammalian female genital system</topic><topic>Middle Aged</topic><topic>postmenopausal endometrium</topic><topic>Postmenopause - metabolism</topic><topic>progesterone receptor</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koshiyama, Masafumi</creatorcontrib><creatorcontrib>Yoshida, Masumi</creatorcontrib><creatorcontrib>Takemura, Maki</creatorcontrib><creatorcontrib>Yura, Yasuichirou</creatorcontrib><creatorcontrib>Matsushita, Katsuko</creatorcontrib><creatorcontrib>Hayashi, Michiharu</creatorcontrib><creatorcontrib>Tauchi, Kunihiko</creatorcontrib><creatorcontrib>Konishi, Ikuo</creatorcontrib><creatorcontrib>Mori, Takahide</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koshiyama, Masafumi</au><au>Yoshida, Masumi</au><au>Takemura, Maki</au><au>Yura, Yasuichirou</au><au>Matsushita, Katsuko</au><au>Hayashi, Michiharu</au><au>Tauchi, Kunihiko</au><au>Konishi, Ikuo</au><au>Mori, Takahide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>1996-08</date><risdate>1996</risdate><volume>75</volume><issue>8</issue><spage>702</spage><epage>706</epage><pages>702-706</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Objective. To examine the expression of sex steroid receptors (ER: estrogen receptor; PR: progesterone receptor) in the postmenopausal endometrium (PMEM) and the relationship to clinical data for studying its characters.
Methods. The immunohistochemical reactivity of the PMEM was studied using monoclonal antibodies against ER and PR, in 33 postmenopausal patients.
Results. The endometrium was thicker in patients who were postmenopausal for 1 to 10 years (1.48±1.31mm) than in patients who were postmenopausal for more than 10 years (0.79 ± 0.37mm) (p<0.05). Among the 33 postmenopausal endometrial samples, ER positivity was found in the glands in 26 cases (78.8%) and PR positivity was detected in 18 cases (54.5%). The average age of the patients with ER positive reactivity in the glands (61.69±7.26 years) was significantly lower than that of the patients with ER negative reactivity (66.00±3.56 years) (p<0.05). Furthermore, the endometrial thickness of the patients with ER or PR positive reactivity in the glands (1.24± 1.09mm and 1.47±1.20mm, respectively) was significantly greater than that of the patients with ER or PR negative reactivity (0.67± 0.26mm and 0.70± 0.40mm, respectively) (p<0.05).
Conclusion. ER in the glands of the PMEM was determined to decrease gradually with increased aging. The presence of ER and PR in the gland cells seemed likely to determine the thickness of the PMEM.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>8906001</pmid><doi>10.3109/00016349609065730</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0001-6349 |
| ispartof | Acta obstetricia et gynecologica Scandinavica, 1996-08, Vol.75 (8), p.702-706 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over aging Aging - physiology Antibodies, Monoclonal Biological and medical sciences endometrial thickness Endometrium - anatomy & histology Endometrium - chemistry estrogen receptor Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Immunohistochemistry Mammalian female genital system Middle Aged postmenopausal endometrium Postmenopause - metabolism progesterone receptor Receptors, Estrogen - analysis Receptors, Progesterone - analysis Vertebrates: reproduction |
| title | Immunohistochemical analysis of distribution of estrogen receptors and progesterone receptors in the postmenopausal endometrium |
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