Dwarf mice and the ageing process

Factors affecting longevity are complex and poorly understood. We have found that Ames dwarf mice (df/df), which are small and deficient in growth hormone (GH), prolactin and thyroid-stimulating hormone (TSH) live significantly longer (P < 0.0001) than their normal siblings. Hereditary dwarfism i...

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Veröffentlicht in:Nature (London) 1996-11, Vol.384 (6604), p.33-33
Hauptverfasser: Brown-Borg, Holly M, Borg, Kurt E, Meliska, Charles J, Bartke, Andrzej
Format: Artikel
Sprache:eng
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Zusammenfassung:Factors affecting longevity are complex and poorly understood. We have found that Ames dwarf mice (df/df), which are small and deficient in growth hormone (GH), prolactin and thyroid-stimulating hormone (TSH) live significantly longer (P < 0.0001) than their normal siblings. Hereditary dwarfism in mice may provide a valuable model for studying the ageing process. The lifespan of an individual depends on genetic and environmental influences. The only well-documented method of extending lifespan is "caloric restriction", as found in rodents. Here we report that genetically dwarf mice live much longer than normal animals from the same strain when maintained under standard laboratory conditions.
ISSN:0028-0836
1476-4687
DOI:10.1038/384033a0