The Pharmacodynamics of 6-(3-Dimethylaminopropionyl)forskolin and a Possible Metabolite in Beagles

A specific gas chromatography/mass spectroscopy method with a detection limit of 0.1ng/mL was developed for the measurement of 6-(3-dimethylaminopropionyl)forskolin (1) in beagle plasma. Using this method, plasma concentrations of 1 in beagles given pharmacologically effective intravenous doses of 1...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1996-04, Vol.85 (4), p.377-380
Hauptverfasser:	Kametani, Shunichi, Matsumoto, Shinichi, Takahira, Takashi, Hosono, Makoto, Hashimoto, Yutaka, Horinishi, Hiroo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Pressure - drug effects Cardiovascular system Colforsin - analogs & derivatives Colforsin - pharmacokinetics Colforsin - pharmacology Dogs Heart Rate - drug effects Hemodynamics - drug effects Infusions, Intravenous Injections, Intravenous Medical sciences Miscellaneous Pharmacology. Drug treatments Stimulation, Chemical Vasodilator Agents - pharmacokinetics Vasodilator Agents - pharmacology Ventricular Pressure - drug effects
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Zusammenfassung:	A specific gas chromatography/mass spectroscopy method with a detection limit of 0.1ng/mL was developed for the measurement of 6-(3-dimethylaminopropionyl)forskolin (1) in beagle plasma. Using this method, plasma concentrations of 1 in beagles given pharmacologically effective intravenous doses of 1·HCl were determined. The observed maximal plasma concentrations rapidly decreased with time, and half-lives of the α-phases were
ISSN:	0022-3549 1520-6017
DOI:	10.1021/js930234z