9.4 T Imaging Studies of Human Tumor Xenografts in Nude Mice

9.4 T Imaging Studies of Human Tumor Xenografts in Nude Mice

To evaluate the potential of 9.4 T imaging in distinguishing normal and neoplastic tissues, we examined the progressive growth of human colon and prostate adenocarcinoma xenografts in nude mice. Images were obtained with a resolution of 100 X 100 X 650 μm, and tumors were clearly distinguished from...

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Veröffentlicht in:Investigative radiology 1988-09, Vol.23 (9), p.677-679
Hauptverfasser: SARKAR, SUSANTA K, MATTINGLY, MARK A, KLINE, THOMAS, GREIG, RUSSELL
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - diagnosis
Animals
Colonic Neoplasms - diagnosis
Female
Humans
Magnetic Resonance Imaging
Male
Mice
Mice, Nude
Neoplasm Transplantation
Prostatic Neoplasms - diagnosis
Transplantation, Heterologous
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Zusammenfassung:To evaluate the potential of 9.4 T imaging in distinguishing normal and neoplastic tissues, we examined the progressive growth of human colon and prostate adenocarcinoma xenografts in nude mice. Images were obtained with a resolution of 100 X 100 X 650 μm, and tumors were clearly distinguished from normal tissue with high contrast. These results demonstrate the feasibility of detecting small human tumors in live nude mice with microscopic resolution at 9.4 T.
ISSN:0020-9996
1536-0210