Renal effects of fenoldopam in refractory hypertension

Renal effects of fenoldopam in refractory hypertension

Fenoldopam, a dopamine-1 (D1) agonist, was administered by a 6-h intravenous infusion to patients with refractory hypertension [diastolic blood pressure (DBP) >115 mmHg while on triple therapy] in order to achieve a fall in DBP of 30 mmHg. The evolution of blood pressure, heart rate, glomerular f...

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Veröffentlicht in:Journal of hypertension 1988-08, Vol.6 (8), p.665-669
Hauptverfasser: Ruilope, Luis M, Robles, Rafael Garcia, Miranda, Blanca, Tovar, Julia, Alcazar, José M, Sancho, José, Rodicio, José L, Martinez, Adelaida, Astorga, Antonia, Beck, Thomas
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Benzazepines - therapeutic use
Female
Fenoldopam
Humans
Hypertension - drug therapy
Hypertension - urine
Kidney - drug effects
Male
Middle Aged
Vasodilator Agents - therapeutic use
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Zusammenfassung:Fenoldopam, a dopamine-1 (D1) agonist, was administered by a 6-h intravenous infusion to patients with refractory hypertension [diastolic blood pressure (DBP) >115 mmHg while on triple therapy] in order to achieve a fall in DBP of 30 mmHg. The evolution of blood pressure, heart rate, glomerular filtration rate (GFR), renal plasma flow (RPF), urine volume, renal excretion of sodium, potassium, chloride, calcium, uric acid, phosphate, plasma renin activity (PRA), aldosterone and prolactin were evaluated. A significant fall in blood pressure (P
ISSN:0263-6352
1473-5598
DOI:10.1097/00004872-198808000-00010